PVRIG Protein, Human (Biotinylated, HEK293, Fc-Avi)

The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived PVRIG protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

PVRIG (PVR-related immunoglobulin domain-containing) protein is identified as a cell surface receptor for NECTIN2, functioning as a potential coinhibitory receptor that dampens T-cell receptor-mediated signals. Upon interacting with NECTIN2, PVRIG exerts its inhibitory effect by suppressing T-cell proliferation. Notably, PVRIG engages in a competitive binding scenario with CD226 for NECTIN2, implying a regulatory role in immune responses where it competes with an activating receptor. This competitive interaction with CD226 underscores PVRIG's involvement in modulating the delicate balance between activating and inhibitory signals during T-cell activation.

Human

HEK293

C-Avi;C-hFc

Q6DKI7 (T41-D171)

79037  [NCBI]

Partial

Biotin

The single lysine residue in Avitag is biotinylated through an enzymatic reaction.

TPEVWVQVRMEATELSSFTIRCGFLGSGSISLVTVSWGGPNGAGGTTLAVLHPERGIRQWAPARQARWETQSSISLILEGSGASSPCANTTFCCKFASFPEGSWEACGSLPPSSDPGLSAPPTPAPILRAD

Approximately 50-60 kDa,based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.