PVRIG Protein, Cynomolgus (HEK293, His)
Based on 1 Customer Validation
The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived PVRIG protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived PVRIG protein, expressed by HEK293 , with C-6*His labeled tag.
Background
PVRIG (PVR-related immunoglobulin domain-containing) protein is identified as a cell surface receptor for NECTIN2, functioning as a potential coinhibitory receptor that dampens T-cell receptor-mediated signals. Upon interacting with NECTIN2, PVRIG exerts its inhibitory effect by suppressing T-cell proliferation. Notably, PVRIG engages in a competitive binding scenario with CD226 for NECTIN2, implying a regulatory role in immune responses where it competes with an activating receptor. This competitive interaction with CD226 underscores PVRIG's involvement in modulating the delicate balance between activating and inhibitory signals during T-cell activation.
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-6*His
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Accession
A0A2K5WVV8 (T41-D171)
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Molecular Construction
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N-term
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PVRIG (T41-D171)
Accession # A0A2K5WVV8 -
6*His
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C-term
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Protein Length
Partial
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Synonyms
PVRIG; Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein; PVR Related Immunoglobulin Domain Containing; Poliovirus Receptor Related Immunoglobulin Domain Containing; C7orf15; Transmembrane Protein PVRIG; CD112R; Nectin-2 Receptor; CD112
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AA Sequence
TPEVWVQVQMEATELSSFTVHCGFLGPGSISLVTVSWGGPDGAGGTKLAVLHPELGTRQWAPARQARWETQSSISLALEDSGASSPFANTTFCCKFASFPEGSWESCGSLPPSSDPGLSAPPTPVPILRAD
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Predicted Molecular Mass
14.5 kDa
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Molecular Weight
Approximately 20-30 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
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Data Sheet (236 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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