1. Stem Cell/Wnt
  2. Notch

LY3039478 (Synonyms: Crenigacestat)

Cat. No.: HY-12449 Purity: 98.01%
Data Sheet SDS Handling Instructions

LY3039478 is a novel and potent Notch inhibitor.

For research use only. We do not sell to patients.
LY3039478 Chemical Structure

LY3039478 Chemical Structure

CAS No. : 1421438-81-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 172 In-stock
2 mg USD 96 In-stock
5 mg USD 168 In-stock
10 mg USD 264 In-stock
25 mg USD 528 In-stock
50 mg USD 840 In-stock
100 mg USD 1320 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

Description

LY3039478 is a novel and potent Notch inhibitor. In a xenograft tumor model, LY3039478 inhibit N1ICD cleavage and expression of Notch-regulated genes in the tumor microenvironment. LY3039478 is being investigated in Phase I.

Clinical Trial
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Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.1531 mL 10.7657 mL 21.5313 mL
5 mM 0.4306 mL 2.1531 mL 4.3063 mL
10 mM 0.2153 mL 1.0766 mL 2.1531 mL
Please refer to the solubility information to select the appropriate solvent.
Molecular Weight

464.44

Formula

C₂₂H₂₃F₃N₄O₄

CAS No.

1421438-81-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 34 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.01%

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Product Name:
LY3039478
Cat. No.:
HY-12449
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