1. Stem Cell/Wnt
  2. Notch

LY3039478 (Synonyms: Crenigacestat)

Cat. No.: HY-12449 Purity: 98.01%
Handling Instructions

LY3039478 is a novel and potent Notch inhibitor.

For research use only. We do not sell to patients.

LY3039478 Chemical Structure

LY3039478 Chemical Structure

CAS No. : 1421438-81-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 172 In-stock
Estimated Time of Arrival: December 31
2 mg USD 96 In-stock
Estimated Time of Arrival: December 31
5 mg USD 168 In-stock
Estimated Time of Arrival: December 31
10 mg USD 264 In-stock
Estimated Time of Arrival: December 31
25 mg USD 528 In-stock
Estimated Time of Arrival: December 31
50 mg USD 840 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

    LY3039478 purchased from MCE. Usage Cited in: Shijie Huaren Xiaohua Zazhi. 2018; 26(17): 1029-1035.

    Effects of flavonoids from Rabdosia serra (Maxim.) Hara on proliferation, migration, and invasion of hepatocellular carcinoma cells
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    Description

    LY3039478 is a novel and potent Notch inhibitor. In a xenograft tumor model, LY3039478 inhibit N1ICD cleavage and expression of Notch-regulated genes in the tumor microenvironment. LY3039478 is being investigated in Phase I.

    Clinical Trial
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 34 mg/mL (73.21 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1531 mL 10.7657 mL 21.5313 mL
    5 mM 0.4306 mL 2.1531 mL 4.3063 mL
    10 mM 0.2153 mL 1.0766 mL 2.1531 mL
    *Please refer to the solubility information to select the appropriate solvent.
    Molecular Weight

    464.44

    Formula

    C₂₂H₂₃F₃N₄O₄

    CAS No.

    1421438-81-4

    SMILES

    O=C(N[[email protected]@H](C)C(N[[email protected]]1C2=CC=CC=C2C3=CC=CN=C3N(CCO)C1=O)=O)CCC(F)(F)F

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 98.01%

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    Product Name:
    LY3039478
    Cat. No.:
    HY-12449
    Quantity:

    LY3039478

    Cat. No.: HY-12449