847925-91-1
847925-91-1
Chemical Structure
RO4929097
- CAS No.: 847925-91-1
- Formula:C22H20F5N3O3
- Molecular Weight:469.40
IUPAC Name: (S)-2,2-dimethyl-N1-(6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N3-(2,2,3,3,3-pentafluoropropyl)malonamide
InChIKey: OJPLJFIFUQPSJR-INIZCTEOSA-N
SMILES: O=C(C(C)(C(NCC(F)(C(F)(F)F)F)=O)C)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O
Biological Activity: RO4929097 is an orally active γ secretase inhibitor with an IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RO4929097 | 98.64% | RO4929097 is an orally active γ secretase inhibitor with an IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. | ||||||||||||||||||||
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RO4929097 (Standard) | ≥98% | RO4929097 (Standard) is the analytical standard of RO4929097 (HY-11102). This product is intended for research and analytical applications. RO4929097 (RG-4733) is an orally active γ secretase inhibitor with an IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.58
HY-18614LY900009 -
Similarity Score 0.55
HY-13526GYO-01027 (GMP) -
Similarity Score 0.54
HY-50752LY-411575 -
Similarity Score 0.54
HY-50752ALY-411575 (isomer 1) -
Similarity Score 0.54
HY-50752BLY-411575 (isomer 2) -
Similarity Score 0.54
HY-50752CLY-411575 (isomer 3) -
Similarity Score 0.54
HY-12449Crenigacestat -
Similarity Score 0.45
HY-120384AZD-0284 -
Similarity Score 0.45
HY-128353ROR agonist-1 -
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