Jagged-1 (188-204) TFA

Name: Jagged-1 (188-204) TFA
Brand: MedChemExpress
SKU: HY-P1846A
Rating: 5.0 (16 reviews)

Cat. No.: HY-P1846A Purity: 99.41%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 16 publication(s) in Google Scholar

Other Forms of Jagged-1 (188-204) TFA:

Jagged-1 (188-204) In-stock

16 Publications Citing Use of MCE Jagged-1 (188-204) TFA

Cell Proliferation/Viability Assay

Cell Imaging/Staining

: Jagged-1 (188-204) TFA purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2025 May;55(5):77. [Abstract]; Jagged-1 (188-204) TFA pretreatment (4 μM; 8 h) significantly increased Notch1 and Hes-1 protein expression levels and decreased Bax and cleaved caspase-3 protein expression levels in H1703 cells.

: Jagged-1 (188-204) TFA purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2025 May;55(5):77. [Abstract]; Jagged-1 (188-204) TFA pretreatment (4 μM; 8 h) significantly decreased P-eIF2α and Grp78 protein expression levels and P-eIF2α/eIF2α ratio in H1703 cells.

: Jagged-1 (188-204) TFA purchased from MedChemExpress. Usage Cited in: Int J Radiat Oncol Biol Phys. 2024 Sep 10:S0360-3016(24)03330-3. [Abstract]; Jagged-1 (188-204) TFA (JAG-1) (25-100 μM) significantly increased the proliferation rate of RIG-3 cells.

: Jagged-1 (188-204) TFA purchased from MedChemExpress. Usage Cited in: Int J Radiat Oncol Biol Phys. 2024 Sep 10:S0360-3016(24)03330-3. [Abstract]; Jagged-1 (188-204) TFA (JAG-1) (100 μM) increased the mitotic activity of RIG-3 cells.

: Jagged-1 (188-204) TFA purchased from MedChemExpress. Usage Cited in: Inflammation. 2022 Dec;45(6):2449-2464. [Abstract]; Jagged-1 (188-204) TFA (10 μM; 4 h). The protein expression levels of Notch1 and Hes1 in the RSV-treated HT-29 cell inflammation model were determined by Western blot analysis.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Jagged-1 (188-204) TFA (40 μM, 72 h) mediates notch signaling activation to induce complete maturation of human keratinocyte by NF-kappaB and PPARgamma^[2].
Jagged-1 (188-204) TFA (50 μM, 24 h) can enhance storage operation of Ca²⁺ entry in human pulmonary artery smooth muscle cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2221.42

Formula

C₉₅H₁₂₈F₃N₂₅O₂₈S₃

Appearance

Solid

Color

White to off-white

Sequence

Cys-Asp-Asp-Tyr-Tyr-Tyr-Gly-Phe-Gly-Cys-Asn-Lys-Phe-Cys-Arg-Pro-Arg

Sequence Shortening

CDDYYYGFGCNKFCRPR

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL (22.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 25 mg/mL (11.25 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.4502 mL	2.2508 mL	4.5016 mL
5 mM	0.0900 mL	0.4502 mL	0.9003 mL
10 mM	0.0450 mL	0.2251 mL	0.4502 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (242 KB) RP-HPLC (203 KB) MS (74 KB)

Handling Instructions (2659 KB)

References

[1]. Jundt F, et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood. 2004 May 1;103(9):3511-5. [Content Brief]

[2]. Nickoloff BJ, et al. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ. 2002 Aug;9(8):842-55. [Content Brief]

[3]. Yamamura H, et al. Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol. 2014 May 1;306(9):C871-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	0.4502 mL	2.2508 mL	4.5016 mL	11.2541 mL
	5 mM	0.0900 mL	0.4502 mL	0.9003 mL	2.2508 mL
	10 mM	0.0450 mL	0.2251 mL	0.4502 mL	1.1254 mL
DMSO	15 mM	0.0300 mL	0.1501 mL	0.3001 mL	0.7503 mL
DMSO	20 mM	0.0225 mL	0.1125 mL	0.2251 mL	0.5627 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.