Jagged-1 (188-204) (TFA)

Name: Jagged-1 (188-204) (TFA)
Brand: MedChemExpress
SKU: HY-P1846A
Rating: 5.0 (5 reviews)

Cat. No.: HY-P1846A Purity: 99.89%: FAQs
Data Sheet SDS COA Handling Instructions

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Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Jagged-1 (188-204) (TFA) Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 750	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Jagged-1 (188-204) (TFA):

Jagged-1 (188-204) Get quote

5 Publications Citing Use of MCE Jagged-1 (188-204) (TFA)

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Jagged-1 (188-204) TFA (40 μM, 72 h) mediates notch signaling activation to induce complete maturation of human keratinocyte by NF-kappaB and PPARgamma^[2].
Jagged-1 (188-204) TFA (50 μM, 24 h) can enhance storage operation of Ca²⁺ entry in human pulmonary artery smooth muscle cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2221.42

Formula

C₉₅H₁₂₈F₃N₂₅O₂₈S₃

Appearance

Solid

Color

White to off-white

Sequence Shortening

CDDYYYGFGCNKFCRPR

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (22.51 mM; Need ultrasonic)

DMSO : 50 mg/mL (22.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.4502 mL	2.2508 mL	4.5016 mL
5 mM	0.0900 mL	0.4502 mL	0.9003 mL
10 mM	0.0450 mL	0.2251 mL	0.4502 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (242 KB) RP-HPLC (203 KB) MS (74 KB) Elemental Analysis Report (102 KB)

Handling Instructions (2659 KB)

References

[1]. Jundt F, et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood. 2004 May 1;103(9):3511-5. [Content Brief]

[2]. Nickoloff BJ, et al. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ. 2002 Aug;9(8):842-55. [Content Brief]

[3]. Yamamura H, et al. Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol. 2014 May 1;306(9):C871-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	0.4502 mL	2.2508 mL	4.5016 mL	11.2541 mL
	5 mM	0.0900 mL	0.4502 mL	0.9003 mL	2.2508 mL
	10 mM	0.0450 mL	0.2251 mL	0.4502 mL	1.1254 mL
	15 mM	0.0300 mL	0.1501 mL	0.3001 mL	0.7503 mL
	20 mM	0.0225 mL	0.1125 mL	0.2251 mL	0.5627 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.