Jagged-1 (188-204) TFA
Based on 18 publication(s) in Google Scholar
Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells.
For research use only. We do not sell to patients.
- Purity: 99.41%
- Formula: C95H128F3N25O28S3
- Molecular Weight:2221.42
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Jagged-1 (188-204) TFA
More- Int J Mol Med. 2025 May;55(5):77. [Abstract]
- Cell Prolif. 2023 Aug;56(8):e13427. [Abstract]
- Br J Pharmacol. 2026 Jul;183(13):3578-3598. [Abstract]
- Int J Radiat Oncol Biol Phys. 2025 Feb 1;121(2):520-533. [Abstract]
- Biochem Pharmacol. 2026 Jul:249:117901. [Abstract]
- Life Sci. 2023 Sep 1:328:121921. [Abstract]
- Int J Mol Sci. 2025 Jan 1;26(1):307. [Abstract]
- Inflammation. 2022 Dec;45(6):2449-2464. [Abstract]
- Biomedicines. 2026 May 22;14(6):1180. [Abstract]
- FASEB J. 2025 Jan 31;39(2):e70364. [Abstract]
- Pathol Res Pract. 2025 Sep 8:275:156217. [Abstract]
- J Biochem Mol Toxicol. 2025 Feb;39(2):e70129. [Abstract]
- Exp Cell Res. 2025 Oct 1;452(2):114711. [Abstract]
- J Appl Toxicol. 2023 Nov;43(11):1702-1718. [Abstract]
- BMC Nephrol. 2025 Apr 17;26(1):196. [Abstract]
- World J Gastrointest Oncol. 2024 Nov 15;16(11):4456-4467. [Abstract]
- Heliyon. 2024 Jun 27;10(13):e33803. [Abstract]
- Research Square Preprint. 2022 May.
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Cell Imaging/Staining
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Biological Activity
Jagged-1 (188-204) TFA (40 μM, 72 h) mediates notch signaling activation to induce complete maturation of human keratinocyte by NF-kappaB and PPARgamma[2].
Jagged-1 (188-204) TFA (50 μM, 24 h) can enhance storage operation of Ca2+ entry in human pulmonary artery smooth muscle cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 2221.42
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Formula C95H128F3N25O28S3
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Color White to off-white
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Sequence
Cys-Asp-Asp-Tyr-Tyr-Tyr-Gly-Phe-Gly-Cys-Asn-Lys-Phe-Cys-Arg-Pro-Arg
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Sequence Shortening
CDDYYYGFGCNKFCRPR
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (18)
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Journal Impact Factor
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Most Recent
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Int J Mol Med
Hesperetin induces apoptosis in lung squamous carcinoma cells via G2/M cycle arrest, inhibition of the Notch1 pathway and activation of endoplasmic reticulum stress. [Abstract]2025 May;55(5):77. PMID: 40084686
Jagged-1 (188-204) TFA purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2025 May;55(5):77. [Abstract]
Jagged-1 (188-204) TFA pretreatment (4 μM; 8 h) significantly increased Notch1 and Hes-1 protein expression levels and decreased Bax and cleaved caspase-3 protein expression levels in H1703 cells.
Jagged-1 (188-204) TFA purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2025 May;55(5):77. [Abstract]
Jagged-1 (188-204) TFA pretreatment (4 μM; 8 h) significantly decreased P-eIF2α and Grp78 protein expression levels and P-eIF2α/eIF2α ratio in H1703 cells.
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Cell Prolif
Perturbation of intestinal stem cell homeostasis and radiation enteritis recovery via dietary titanium dioxide nanoparticles. [Abstract]2023 Aug;56(8):e13427. PMID: 36798041 -
Br J Pharmacol
Cordycepin alleviates ischaemic brain injury by suppressing microglia-induced neuroinflammation via regulating the Notch1 signalling pathway. [Abstract]2026 Jul;183(13):3578-3598. PMID: 41913462 -
Int J Radiat Oncol Biol Phys
Single-Nucleus RNA-Sequencing Reveals a MET+ Oligodendrocyte Subpopulation That Promotes Proliferation of Radiation-Induced Gliomas. [Abstract]2025 Feb 1;121(2):520-533. PMID: 39265740
Jagged-1 (188-204) TFA purchased from MedChemExpress. Usage Cited in: Int J Radiat Oncol Biol Phys. 2025 Feb 1;121(2):520-533. [Abstract]
Jagged-1 (188-204) TFA (JAG-1) (25-100 μM) significantly increased the proliferation rate of RIG-3 cells.
Jagged-1 (188-204) TFA purchased from MedChemExpress. Usage Cited in: Int J Radiat Oncol Biol Phys. 2025 Feb 1;121(2):520-533. [Abstract]
Jagged-1 (188-204) TFA (JAG-1) (100 μM) increased the mitotic activity of RIG-3 cells.
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Biochem Pharmacol
Endothelial Foxp1 overexpression inhibits endothelial-to-mesenchymal transition via suppressing Notch pathway activation to attenuate valvular calcification in chronic kidney disease. [Abstract]2026 Jul:249:117901. PMID: 41839241 -
Life Sci
Ferulic acid, ligustrazine, and tetrahydropalmatine display the anti-proliferative effect in endometriosis through regulating Notch pathway. [Abstract]2023 Sep 1:328:121921. PMID: 37429417 -
Int J Mol Sci
2025 Jan 1;26(1):307. PMID: 39796164 -
Inflammation
Effects of Resveratrol on Tight Junction Proteins and the Notch1 Pathway in an HT-29 Cell Model of Inflammation Induced by Lipopolysaccharide. [Abstract]2022 Dec;45(6):2449-2464. PMID: 35705831
Jagged-1 (188-204) TFA purchased from MedChemExpress. Usage Cited in: Inflammation. 2022 Dec;45(6):2449-2464. [Abstract]
Jagged-1 (188-204) TFA (10 μM; 4 h). The protein expression levels of Notch1 and Hes1 in the RSV-treated HT-29 cell inflammation model were determined by Western blot analysis.
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Biomedicines
Myeloid-Specific Deletion of Lnx2 Attenuates Estrogen-Deficiency-Induced Bone Loss by Inhibiting Osteoclastogenesis via the NUMB/NOTCH2 Axis. [Abstract]2026 May 22;14(6):1180. PMID: 42351608 -
FASEB J
Salvianolic acid A promotes bone-fracture healing via balancing osteoblast and osteoclast differentiation. [Abstract]2025 Jan 31;39(2):e70364. PMID: 39878631 -
Pathol Res Pract
USP41 regulates glioma malignancy through Notch1 activation: Insights from in vitro and in vivo studies. [Abstract]2025 Sep 8:275:156217. PMID: 40946423 -
J Biochem Mol Toxicol
Estrogen Promotes the Proliferation and Migration of Endometrial Cancer Through the GPER-Mediated NOTCH Pathway. [Abstract]2025 Feb;39(2):e70129. PMID: 39878097 -
Exp Cell Res
NOTCH signaling orchestrates the inflammatory-fibrotic continuum of macrophages in renal allograft rejection. [Abstract]2025 Oct 1;452(2):114711. PMID: 40912393 -
J Appl Toxicol
Emodin disrupts the Notch1/Nrf2/GPX4 antioxidant system and promotes renal cell ferroptosis. [Abstract]2023 Nov;43(11):1702-1718. PMID: 37393915 -
BMC Nephrol
Study on effect of pancreatic kininogenase on diabetic nephropathy-induced fibrosis via Notch1/Hes1/Pten/Akt signaling pathway. [Abstract]2025 Apr 17;26(1):196. PMID: 40247227 -
World J Gastrointest Oncol
Impact and mechanism study of dioscin on biological characteristics of colorectal cancer cells. [Abstract]2024 Nov 15;16(11):4456-4467. PMID: 39554744 -
Heliyon
Agrimonolide mitigated DSS-induced colitis by modulating the balance between Treg and Th17 cells through the suppression of the Notch and JAK2/STAT3 signaling pathways. [Abstract]2024 Jun 27;10(13):e33803. PMID: 39071599 -
Solvent & Solubility
DMSO : ≥ 50 mg/mL (22.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 25 mg/mL (11.25 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Jundt F, et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood. 2004 May 1;103(9):3511-5. [Content Brief]
[2]. Nickoloff BJ, et al. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ. 2002 Aug;9(8):842-55. [Content Brief]
[3]. Yamamura H, et al. Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol. 2014 May 1;306(9):C871-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 0.4502 mL | 2.2508 mL | 4.5016 mL | 11.2541 mL |
| 5 mM | 0.0900 mL | 0.4502 mL | 0.9003 mL | 2.2508 mL | |
| 10 mM | 0.0450 mL | 0.2251 mL | 0.4502 mL | 1.1254 mL | |
| DMSO | 15 mM | 0.0300 mL | 0.1501 mL | 0.3001 mL | 0.7503 mL |
| 20 mM | 0.0225 mL | 0.1125 mL | 0.2251 mL | 0.5627 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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