Jagged-1 (188-204)

Name: Jagged-1 (188-204)
Brand: MedChemExpress
SKU: HY-P1846
Rating: 5.0 (16 reviews)

Cat. No.: HY-P1846 Purity: 99.72%: Data Sheet
COA

SDS
Handling Instructions
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Jagged-1 (188-204) is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CAS No. : 219127-21-6

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 16 publication(s) in Google Scholar

Other Forms of Jagged-1 (188-204):

Jagged-1 (188-204) TFA In-stock

16 Publications Citing Use of MCE Jagged-1 (188-204)

Cell Proliferation/Viability Assay

Cell Imaging/Staining

: Jagged-1 (188-204) purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2025 May;55(5):77. [Abstract]; Jagged-1 (188-204) TFA pretreatment (4 μM; 8 h) significantly increased Notch1 and Hes-1 protein expression levels and decreased Bax and cleaved caspase-3 protein expression levels in H1703 cells.

: Jagged-1 (188-204) purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2025 May;55(5):77. [Abstract]; Jagged-1 (188-204) TFA pretreatment (4 μM; 8 h) significantly decreased P-eIF2α and Grp78 protein expression levels and P-eIF2α/eIF2α ratio in H1703 cells.

: Jagged-1 (188-204) purchased from MedChemExpress. Usage Cited in: Int J Radiat Oncol Biol Phys. 2024 Sep 10:S0360-3016(24)03330-3. [Abstract]; Jagged-1 (188-204) TFA (JAG-1) (25-100 μM) significantly increased the proliferation rate of RIG-3 cells.

: Jagged-1 (188-204) purchased from MedChemExpress. Usage Cited in: Int J Radiat Oncol Biol Phys. 2024 Sep 10:S0360-3016(24)03330-3. [Abstract]; Jagged-1 (188-204) TFA (JAG-1) (100 μM) increased the mitotic activity of RIG-3 cells.

: Jagged-1 (188-204) purchased from MedChemExpress. Usage Cited in: Inflammation. 2022 Dec;45(6):2449-2464. [Abstract]; Jagged-1 (188-204) TFA (10 μM; 4 h). The protein expression levels of Notch1 and Hes1 in the RSV-treated HT-29 cell inflammation model were determined by Western blot analysis.

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Description

In Vitro

Jagged-1 (188-204) is part of the DSL region, and highly conserved between human Jagged-1 and Jagged-2^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2107.40

Formula

C₉₃H₁₂₇N₂₅O₂₆S₃

CAS No.

219127-21-6

Appearance

Solid

Color

White to off-white

Sequence

Cys-Asp-Asp-Tyr-Tyr-Tyr-Gly-Phe-Gly-Cys-Asn-Lys-Phe-Cys-Arg-Pro-Arg

Sequence Shortening

CDDYYYGFGCNKFCRPR

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 3.33 mg/mL (1.58 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.4745 mL	2.3726 mL	4.7452 mL
5 mM	---	---	---
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.72%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (243 KB) RP-HPLC (97 KB) MS (101 KB)

Handling Instructions (2659 KB)

References

[1]. Jundt F, et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood. 2004 May 1;103(9):3511-5. [Content Brief]

[2]. Weijzen S, et al. The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendriticcells. J Immunol. 2002 Oct 15;169(8):4273-8. [Content Brief]

[3]. Nickoloff BJ, et al. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ. 2002 Aug;9(8):842-55. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O

1 mM

0.4745 mL

2.3726 mL

4.7452 mL

11.8630 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Jagged-1 (188-204) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Jagged-1 (188-204)219127-21-6NotchJagged-1multiple myelomahuman dendritic cellsDSL regionInhibitorinhibitorinhibit

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Jagged-1 (188-204)

Customer Review

Other Forms of Jagged-1 (188-204):

Jagged-1 (188-204) Related Antibodies

16 Publications Citing Use of MCE Jagged-1 (188-204)

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Complete Stock Solution Preparation Table

Jagged-1 (188-204) Related Classifications

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