Jagged-1 (188-204) 

Jagged-1 (188-204) is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells^[1][2][3].

Jagged-1 (188-204) is part of the DSL region, and highly conserved between human Jagged-1 and Jagged-2^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2107.40

C₉₃H₁₂₇N₂₅O₂₆S₃

219127-21-6

Cys-Asp-Asp-Tyr-Tyr-Tyr-Gly-Phe-Gly-Cys-Asn-Lys-Phe-Cys-Arg-Pro-Arg

CDDYYYGFGCNKFCRPR

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jundt F, et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood. 2004 May 1;103(9):3511-5.  [Content Brief]

  [2]. Weijzen S, et al. The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendriticcells. J Immunol. 2002 Oct 15;169(8):4273-8.  [Content Brief]

  [3]. Nickoloff BJ, et al. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ. 2002 Aug;9(8):842-55.  [Content Brief]