Lumiflavin
Based on 1 publication(s) in Google Scholar
Lumiflavin (Lumiflavine), a riboflavine analog, causes significant inhibition of riboflavine uptake. Lumiflavin can effectively reduce the riboflavin enrichment in cancer stem-like cells (CSCs) and sensitize the effect of cisplatin Diamminedichloroplatinum (DDP) on CSCs. Lumiflavin is promising for research of ovarian cancer.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 1088-56-8
- Formula: C13H12N4O2
- Molecular Weight:256.26
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Lumiflavin
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Biological Activity
Lumiflavin (10-40 μM, 48 h) has synergistic effects with Diamminedichloroplatinum (DDP) (20 μM, 48 h) on CSCs in increasing mitochondrial function damage and apoptosis rates and decreasing clonic function[2].
Lumiflavin (0-80 μM, 72 h) reduces the formation of drug resistance and proportion of CSCs, increases CSCs/DDP apoptosis rate and reduces cell clone formation ability in ovarian cancer cell line OVCAR-3[3].
Lumiflavin (80 μM, 72 h) downregulates the protein expression of Notch signaling pathway in CSCs/DDP[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:OVCAR-3
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Concentration:0-80 μM
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Incubation Time:72 h
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Result:Reduced the drug resistance of OVCAR-3/DDP cells significantly.
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Cell Line:CSCs/DDP
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Concentration:80 μM
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Incubation Time:72 h
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Result:Increased Notch-1, Notch-2, Notch-3, and Notch ligands, just as Jag1, 2 and Dll 1, 3, 4, whereas the expressions of Notch-1, Notch-2, Notch-3 and Jag1, 2 and Dll 3 were downregulated.
Lumiflavin (4-16 mg/kg, s.c., once a day for 25 days) combined with DDP reduces tumor weight and inhibits tumor growth[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice[3]
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Dosage:4-16 mg/kg
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Administration:s.c., once a day for 25 days
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Result:Reduced tumor weight and inhibited tumor growth curve combined with DDP in a dose-dependent manner.
Chemical Information
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CAS No. 1088-56-8
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Appearance Solid
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Molecular Weight 256.26
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Formula C13H12N4O2
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Color Light yellow to yellow
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SMILES
CC1=CC2=C(N(C(C3=N2)=NC(NC3=O)=O)C)C=C1C
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Synonyms
Lumiflavine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
FAD synthase confers ferroptosis resistance and restrains CD8+ T cell recruitment in hepatocellular carcinoma. [Abstract]2025 Oct 29;16(1):9547. PMID: 41162372
Solvent & Solubility
0.1 M NaOH : 10 mg/mL (39.02 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. H M Said, et al. Mechanism of riboflavine uptake by Caco-2 human intestinal epithelial cells. Am J Physiol. 1994 Jan;266(1 Pt 1):G15-21. [Content Brief]
[2]. Yang R, et al. Lumiflavin increases the sensitivity of ovarian cancer stem-like cells to cisplatin by interfering with riboflavin. J Cell Mol Med. 2019 Aug;23(8):5329-5339. [Content Brief]
[3]. Yang R, et al. Lumiflavin Reduces Cisplatin Resistance in Cancer Stem-Like Cells of OVCAR-3 Cell Line by Inducing Differentiation. Front Oncol. 2022 May 20;12:859275. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 0.1 M NaOH | 1 mM | 3.9023 mL | 19.5114 mL | 39.0229 mL | 97.5572 mL |
| 5 mM | 0.7805 mL | 3.9023 mL | 7.8046 mL | 19.5114 mL | |
| 10 mM | 0.3902 mL | 1.9511 mL | 3.9023 mL | 9.7557 mL | |
| 15 mM | 0.2602 mL | 1.3008 mL | 2.6015 mL | 6.5038 mL | |
| 20 mM | 0.1951 mL | 0.9756 mL | 1.9511 mL | 4.8779 mL | |
| 25 mM | 0.1561 mL | 0.7805 mL | 1.5609 mL | 3.9023 mL | |
| 30 mM | 0.1301 mL | 0.6504 mL | 1.3008 mL | 3.2519 mL |
Lumiflavin Related Classifications
HY-121608 Related Classifications
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