1088-56-8
Chemical Structure
Lumiflavin
Synonym(s): Lumiflavine
- CAS No.: 1088-56-8
- Formula:C13H12N4O2
- Molecular Weight:256.26
IUPAC Name: 7,8,10-trimethylbenzo[g]pteridine-2,4(3H,10H)-dione
InChIKey: KPDQZGKJTJRBGU-UHFFFAOYSA-N
SMILES: CC1=CC2=C(N(C(C3=N2)=NC(NC3=O)=O)C)C=C1C
Biological Activity: Lumiflavin (Lumiflavine), a riboflavine analog, causes significant inhibition of riboflavine uptake. Lumiflavin can effectively reduce the riboflavin enrichment in cancer stem-like cells (CSCs) and sensitize the effect of cisplatin Diamminedichloroplatinum (DDP) on CSCs. Lumiflavin is promising for research of ovarian cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lumiflavin | 99.79% | Lumiflavin (Lumiflavine), a riboflavine analog, causes significant inhibition of riboflavine uptake. Lumiflavin can effectively reduce the riboflavin enrichment in cancer stem-like cells (CSCs) and sensitize the effect of cisplatin Diamminedichloroplatinum (DDP) on CSCs. Lumiflavin is promising for research of ovarian cancer. | ||||||||||||||||||||
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- [1]. H M Said, et al. Mechanism of riboflavine uptake by Caco-2 human intestinal epithelial cells. Am J Physiol. 1994 Jan;266(1 Pt 1):G15-21. [Content Brief]
- [2]. Yang R, et al. Lumiflavin increases the sensitivity of ovarian cancer stem-like cells to cisplatin by interfering with riboflavin. J Cell Mol Med. 2019 Aug;23(8):5329-5339. [Content Brief]
- [3]. Yang R, et al. Lumiflavin Reduces Cisplatin Resistance in Cancer Stem-Like Cells of OVCAR-3 Cell Line by Inducing Differentiation. Front Oncol. 2022 May 20;12:859275. [Content Brief]
Keywords
