2. GPCR/G Protein
  3. Adenosine Receptor
  4. Alloxazine

Alloxazine  (Synonyms: Isoalloxazine)

Cat. No.: HY-123085 Purity: 96.29%
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Alloxazine is a selective A2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer.

For research use only. We do not sell to patients.

Alloxazine Chemical Structure

Alloxazine Chemical Structure

CAS No. : 490-59-5

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Based on 1 publication(s) in Google Scholar

Alloxazine Related Antibodies

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Description

Alloxazine is a selective A2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer[1][2].

IC50 & Target

IC50: 2.9 μM (AMP)[1]
In Vitro

Alloxazine (0-30 μM, 20 min) inhibits cyclic AMP production in PGT-β cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alloxazine Related Antibodies

Cell Viability Assay[1]

Cell Line: PGT-β cells
Concentration: 0-30 μM
Incubation Time: 20 min
Result: Inhibited the cyclic AMP generation concentration-dependently with an IC50 of 2.9 μM.
In Vivo

Alloxazine (1 µmol/L; cortical surface suffusion for 0-20 min) suppresses NECA-induced vasodilation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[2]
Dosage: 1 µmol/L
Administration: Cortical surface suffusion; 1 µmol/L once
Result: Significantly suppressed vasodilation with increased EC25 value of 0.60 µmol/L.
Molecular Weight

214.18

Formula

C10H6N4O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1)N=C2NC3=CC=CC=C3N=C2C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (23.34 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6690 mL 23.3449 mL 46.6897 mL
5 mM 0.9338 mL 4.6690 mL 9.3379 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6690 mL 23.3449 mL 46.6897 mL 116.7243 mL
5 mM 0.9338 mL 4.6690 mL 9.3379 mL 23.3449 mL
10 mM 0.4669 mL 2.3345 mL 4.6690 mL 11.6724 mL
15 mM 0.3113 mL 1.5563 mL 3.1126 mL 7.7816 mL
20 mM 0.2334 mL 1.1672 mL 2.3345 mL 5.8362 mL
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Alloxazine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alloxazine490-59-5IsoalloxazineAdenosine ReceptorP1 receptorNECAcancerAMPInhibitorinhibitorinhibit

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