490-59-5
490-59-5
Chemical Structure
Alloxazine
Synonym(s): Isoalloxazine
- CAS 番号: 490-59-5
- Formula:C10H6N4O2
- Molecular Weight:214.18
IUPAC Name: benzo[g]pteridine-2,4(3H,10H)-dione
InChIKey: HAUGRYOERYOXHX-UHFFFAOYSA-N
SMILES: O=C(N1)N=C2NC3=CC=CC=C3N=C2C1=O
Biological Activity: Alloxazine is a selective A2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer[1][2].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Alloxazine | 99.46% | Alloxazine is a selective A2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer. | ||||||||||||||||||||
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Alloxazine (Standard) | ≥98% | Alloxazine (Standard) is the analytical standard of Alloxazine. This product is intended for research and analytical applications. Alloxazine is a selective A2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer. | ||||||||||||||||||||
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BMY 20844 | BMY 20844 is an orally active platelet cAMP phosphodiesterase inhibitor with anti-thrombosis activity. BMY 20844 can elevate cAMP levels and activate protein kinase in platelets. BMY 20844 can be used for the research of cardiovascular disease. | |||||||||||||||||||||
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Ro 08-2750 | 98.01% | Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 μM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM. | ||||||||||||||||||||
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Pyocyanin | 99.23% | Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity. | ||||||||||||||||||||
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2-(3-Chlorophenyl)-1H-benzo[d]imidazole | 2-(3-Chlorophenyl)-1H-benzo[d]imidazole is an antibacterial agent. 2-(3-Chlorophenyl)-1H-benzo[d]imidazole can be used in the research of bacterial infections and fungal infections. | |||||||||||||||||||||
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Lumiflavin | 99.81% | Lumiflavin (Lumiflavine), a riboflavine analog, causes significant inhibition of riboflavine uptake. Lumiflavin can effectively reduce the riboflavin enrichment in cancer stem-like cells (CSCs) and sensitize the effect of cisplatin Diamminedichloroplatinum (DDP) on CSCs. Lumiflavin is promising for research of ovarian cancer. | ||||||||||||||||||||
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ecMetAP-IN-1 | 98.12% | ecMetAP-IN-1 is an inhibitor of E. coli methionine aminopeptidase (ecMetAP) with an IC50 of 2.086 μM. ecMetAP-IN-1 is applicable to research related to bacterial infections caused by E. coli. | ||||||||||||||||||||
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Chlorfenazole | 99.85% | Chlorfenazole (o-Chlorobenzimidazole) is a benzimidazole-based compound. Chlorfenazole is used in the research of intestinal nematode diseases. | ||||||||||||||||||||
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2-(2′-Hydroxyphenyl)benzimidazole | 99.92% | 2-(2′-Hydroxyphenyl) benzimidazole is the most extensively studied excited-state intramolecular proton transfer (ESIPT) molecule, exhibiting normal and tautomer emissions. 2-(2′-Hydroxyphenyl) benzimidazole has been applied as a fluorescent probe in various systems. | ||||||||||||||||||||
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5-Deazaflavin | 95.0% | 5-deazaflavin is a flavin analogue with redox activity. 5-deazaflavin is a photocatalyst in biological redox systems. | ||||||||||||||||||||
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PLK1-IN-9 | PLK1-IN-9 (Compound M2) is an inhibitor for polo-like kinase 1 (PLK1), that inhibits PLK proteins modified with peptides 1010pT, cdc25c and PBIP, with IC50s of 1.6, 0.8 and 1.4 μM, respectively. PLK1-IN-9 inhibits proliferations of cancer cells HeLa, HL60, SNU387/499, HepG2, exhibits cytotoxicity and induces apoptosis. PLK1-IN-9 inhibits tumor growth in HepG2 xenograft mouse model. | |||||||||||||||||||||
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References
- [1]. Brackett LE, Daly JW. Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts. Biochem Pharmacol. 1994 Mar 2;47(5):801-14. [Content Brief]
- [2]. Shin HK, et al. Role of adenosine A(2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation. Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H339-44. [Content Brief]
