490-59-5
490-59-5
Chemical Structure
Alloxazine
Synonym(s): Isoalloxazine
- CAS No.: 490-59-5
- Formula:C10H6N4O2
- Molecular Weight:214.18
IUPAC Name: benzo[g]pteridine-2,4(3H,10H)-dione
InChIKey: HAUGRYOERYOXHX-UHFFFAOYSA-N
SMILES: O=C(N1)N=C2NC3=CC=CC=C3N=C2C1=O
Biological Activity: Alloxazine is a selective A2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer[1][2].
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Alloxazine | 99.46% | Alloxazine is a selective A2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer. | ||||||||||||||||||||
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Alloxazine (Standard) | ≥98% | Alloxazine (Standard) is the analytical standard of Alloxazine. This product is intended for research and analytical applications. Alloxazine is a selective A2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer. | ||||||||||||||||||||
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References
- [1]. Brackett LE, Daly JW. Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts. Biochem Pharmacol. 1994 Mar 2;47(5):801-14. [Content Brief]
- [2]. Shin HK, et al. Role of adenosine A(2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation. Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H339-44. [Content Brief]
