1. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  2. Mps1 Apoptosis
  3. Mps-BAY2a

Mps-BAY2a is a monopolar spindle 1 (MPS1) inhibitor with an IC50 of 1 nM against human MPS1. Mps-BAY2a induces mitotic aberrations and apoptosis in cancer cells.

For research use only. We do not sell to patients.

Mps-BAY2a Chemical Structure

Mps-BAY2a Chemical Structure

CAS No. : 1382477-96-4

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5 mg USD 350 In-stock
10 mg USD 580 In-stock
25 mg USD 1100 In-stock
50 mg USD 1700 In-stock
100 mg USD 2680 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Mps-BAY2a is a monopolar spindle 1 (MPS1) inhibitor with an IC50 of 1 nM against human MPS1. Mps-BAY2a induces mitotic aberrations and apoptosis in cancer cells[1].

IC50 & Target

IC50: 1 nM (human MPS1), 2.6 nM (rat MPS1), 9 nM (mouse MPS1)[1]

Molecular Weight

476.57

Formula

C29H28N6O

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C(C2=CN=C3C(NCC(C)C)=NC(C4=C5C=CC=NC5=CC=C4)=CN32)C=C1)NC6CC6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (20.98 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0983 mL 10.4916 mL 20.9833 mL
5 mM 0.4197 mL 2.0983 mL 4.1967 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0983 mL 10.4916 mL 20.9833 mL 52.4582 mL
5 mM 0.4197 mL 2.0983 mL 4.1967 mL 10.4916 mL
10 mM 0.2098 mL 1.0492 mL 2.0983 mL 5.2458 mL
15 mM 0.1399 mL 0.6994 mL 1.3989 mL 3.4972 mL
20 mM 0.1049 mL 0.5246 mL 1.0492 mL 2.6229 mL
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Mps-BAY2a Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Mps-BAY2a
Cat. No.:
HY-110242
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