1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Mps1
  3. Mps1-IN-1 dihydrochloride

Mps1-IN-1 dihydrochloride 

Cat. No.: HY-110347
Handling Instructions

Mps1-IN-1 dihydrochloride is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM.

For research use only. We do not sell to patients.

Mps1-IN-1 dihydrochloride Chemical Structure

Mps1-IN-1 dihydrochloride Chemical Structure

CAS No. : 1883548-93-3

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Description

Mps1-IN-1 dihydrochloride is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM[1].

IC50 & Target[1]

Mps1

367 nM (IC50)

Mps1

27 nM (Kd)

ALK

21 nM (Kd)

LTK

29 nM (Kd)

PYK2

280 nM (Kd)

FAK

440 nM (IC30)

IGF1R

750 nM (Kd)

INSR

470 nM (Kd)

CLK1

1900 nM (Kd)

ERK2

2900 nM (Kd)

INSRR

1200 nM (Kd)

TNK1

2600 nM (Kd)

TNK2

3100 nM (Kd)

GAK

1100 nM (Kd)

In Vitro

Mps1-IN-1 dihydrochloride is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM. Mps1-IN-1 dihydrochloride also has high affinity for ALK, and LTK, with Kds of 21 and 39 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-1 dihydrochloride (5, 10 μM) induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells. Mps1-IN-1 disrupts recruitment of Mad2 to kinetochores, and reduces the phosphorylation status of Aurora B at threonine-232 (Thr232). Mps1-IN-1 dihydrochloride (10 µM) shows no effect on centrosome duplication. In addition, Mps1-IN-1 dihydrochloride (5-10 µM) suppresses the proliferative capacity of HCT116[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

608.58

Formula

C₂₈H₃₅Cl₂N₅O₄S

CAS No.

1883548-93-3

SMILES

OC1CCN(C2=CC=C(NC3=CC(NC4=CC=CC=C4S(=O)(C(C)C)=O)=C5C(NC=C5)=N3)C(OC)=C2)CC1.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Mps1-IN-1Mps1Monopolar spindle 1Inhibitorinhibitorinhibit

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Mps1-IN-1 dihydrochloride
Cat. No.:
HY-110347
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