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Results for "

TTK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CDK (1) Histone Acetyltransferase (1) JAK (1) Mps1 (5) PROTACs (2) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (10) Neurological Disease (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

TTK21	Histone Acetyltransferase	Neurological Disease
TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 passes the blood–brain barrier, induces no toxicity, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP). TTK21 has beneficial implications for the brain functions of neurogenesis and long-term memory ^[1].CSP-TTK21 can ameliorate Aβ-impaired long-term potentiation (LTP). CSP-TTK21 may enhance the transcription of genes that promote synaptic health and cognitive function . CSP-TTK21 is orally effective and leads to improvements in motor functions, histone acetylation dynamics in a spinal injury rat model .

TTK inhibitor 3	Others	Cancer
TTK inhibitor 3 is a potent and selective *TTK* (an essential spindle assembly checkpoint enzyme) inhibitor with an IC₅₀ value of 3.0 nM.

TTK inhibitor 4	Others	Cancer
TTK inhibitor 4 (compound 16) is a potent inhibitor of threonine tyrosine kinase (TTK), with the IC₅₀ value of 0.016 μM, that has anti-tumor activity .

TTK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TTK Human Pre-designed siRNA Set A contains three designed siRNAs for TTK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TTK Human Pre-designed siRNA Set A TTK Human Pre-designed siRNA Set A

*PROTAC TTK* degrader-2**	PROTACs	Cancer
PROTAC TTK degrader-2 is a potent *TTK* (threonine tyrosine kinase) PROTAC degrader, with DC₅₀ values of 3.1 and 12.4 nM in COLO-205 and HCT-116 cell, respectively. PROTAC TTK degrader-2 exhibits target degradation and anticancer efficacy in a xenograft mouse model of COLO-205 human colorectal cancer cells .

*PROTAC TTK* degrader-1**	PROTACs	Cancer
PROTAC TTK degrader-1 is a potent *TTK* (threonine tyrosine kinase) PROTAC degrader, with DC₅₀ values of 1.7 and 5.8 nM in COLO-205 and HCT-116 cell, respectively. PROTAC TTK degrader-1 exhibits target degradation and anticancer efficacy in a xenograft mouse model of COLO-205 human colorectal cancer cells .

RMS-07	Mps1	Others
RMS-07 is a covalent Monopolar Spindle Kinase 1 (MPS1/TTK) inhibitor, with an apparent IC₅₀ of 13.1 nM. RMS-07 targets a poorly conserved cysteine in the kinase's hinge region .

Luvixasertib hydrochloride 4 Publications Verification CFI-402257 hydrochloride	Mps1	Cancer
CFI-402257 hydrochloride is a highly selective and orally bioavailable *TTK/Mps1* inhibitor with an IC₅₀ of 1.7 nM for TTK in vitro. CFI-402257 hydrochloride has anti-cancer activity .

CC-671 1 Publications Verification	CDK	Cancer
CC-671 is a dual TTK protein kinase/CDC2-like kinase (CLK2) inhibitor with IC₅₀s of 0.005 and 0.006 μM for TTK and CLK2, respectively.

HY-14710

AZ3146

4 Publications Verification

Mps1 Cancer

AZ3146 is a reasonably potent Mps1 and TTK inhibitor, with IC₅₀ of 35 nM for Mps1 ^Cat.
HY-160419

Mps1-IN-8

Mps1 Cancer

Mps1-IN-8 is a Mps1 inhibitor. Mps1-IN-8 can be used in the study of various tumors .
HY-100024

NTRC 0066-0

NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC₅₀=0.9 nM). NTRC 0066-0 can be used for the research of cancer .

AZ3146 4 Publications Verification	Mps1	Cancer
AZ3146 is a reasonably potent Mps1 and TTK inhibitor, with IC₅₀ of 35 nM for Mps1 ^Cat.

Mps1-IN-8	Mps1	Cancer
Mps1-IN-8 is a Mps1 inhibitor. Mps1-IN-8 can be used in the study of various tumors .

NTRC 0066-0
NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC₅₀=0.9 nM). NTRC 0066-0 can be used for the research of cancer .

JAK3-IN-1	JAK	Cancer
JAK3-IN-1 is a potent, selective and orally active JAK3 inhibitor with an IC₅₀ of 4.8 nM. JAK3-IN-1 shows over 180-fold more selective for JAK3 than JAK1 (IC₅₀ of 896 nM) and JAK2 (IC₅₀ of 1050 nM) .

Mps1-IN-1 dihydrochloride	Mps1	Cancer
Mps1-IN-1 dihydrochloride is a potent and ATP-competitive Mps1 kinase inhibitor with an IC₅₀ of 367 nM. Mps1-IN-1 dihydrochloride inhibit Mps1 mitotic kinase activity and abrogates spindle assembly checkpoint (SAC) function. Mps1-IN-1 dihydrochloride decreases the viability of both cancer and ‘normal’ cells .

Cat. No.	Compare	Product Name	Species	Source

	TTK Protein, Human (Sf9, FLAG) TTK; Dual specificity protein kinase TTK; Phosphotyrosine picked threonine-protein kinase; PYT	Human	Sf9 insect cells
	The TTK protein is a highly efficient kinase that phosphorylates proteins on serine, threonine, and tyrosine residues, potentially regulating fundamental cellular processes. Notably, it phosphorylates MAD1L1, promoting mitotic checkpoint signaling, which is critical for accurate chromosome segregation. TTK Protein, Human (Sf9, FLAG) is the recombinant human-derived TTK protein, expressed by Sf9 insect cells , with C-Flag labeled tag and K857G, , , , mutation. The total length of TTK Protein, Human (Sf9, FLAG) is 857 a.a., .

	TTK Protein, Human (Sf9, GST, FLAG) TTK; Dual specificity protein kinase TTK; Phosphotyrosine picked threonine-protein kinase; PYT	Human	Sf9 insect cells
	The TTK protein is a highly efficient kinase that phosphorylates proteins on serine, threonine, and tyrosine residues, potentially regulating fundamental cellular processes. Notably, it phosphorylates MAD1L1, promoting mitotic checkpoint signaling, which is critical for accurate chromosome segregation. TTK Protein, Human (Sf9, GST, FLAG) is the recombinant human-derived TTK protein, expressed by Sf9 insect cells , with C-Flag, N-GST labeled tag and K857G, , , , mutation. The total length of TTK Protein, Human (Sf9, GST, FLAG) is 857 a.a., .


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