PROTAC TTK degrader-2

PROTAC TTK degrader-2 is a threonine tyrosine kinase (TTK) PROTAC degrader with a DC50 of 3.1 nM in COLO-205 cells. PROTAC TTK degrader-2 induces proteasome-mediated degradation of TTK. It inhibits the proliferation of colorectal cancer cells. In colorectal cancer xenograft mouse models, PROTAC TTK degrader-2 mediates target degradation and exerts anticancer activity. PROTAC TTK degrader-2 can be used in colorectal cancer-related research.
(Pink: Mps1 Target protein ligand; Blue: Cereblon ligand (HY-W243404); Black: linker (HY-69220)).

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  • CAS No.: 2953426-48-5
  • Formule: C49H57N9O7
  • Masse moléculaire:884.03
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    Please store the product under the recommended conditions in the Certificate of Analysis.

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