PROTAC TTK degrader-2

PROTAC TTK degrader-2 (compound 8j) potently degrades TTK protein in human colorectal cancer cell line COLO-205, with a DC₅₀ of 3.1 nM and a maximum degradation rate of 82% after 6 h of treatment; it also degrades TTK protein in human colorectal cancer cell line HCT-116, with a DC₅₀ of 12.4 nM and a maximum degradation rate of 77% after 6 h of treatment^[1].
PROTAC TTK degrader-2 (5-50 nM; 6 h) induces dose-dependent TTK degradation in LOVO, HCT-8, HCT-29 and COLO-205 human colorectal cancer cells; it induces TTK degradation in the human colorectal cancer cell line COLO-205, and this degradation persists for 6-8 h after compound washout^[1].
PROTAC TTK degrader-2 (5-50 nM; 6 h) induces TTK degradation in human colorectal cancer cell line COLO-205 via a proteasome-dependent and TTK binding-required mechanism^[1].
PROTAC TTK degrader-2 (0.000508-10 μM; 96 h) potently inhibits the proliferation of human colorectal cancer cell line COLO-205, with an IC₅₀ of 0.2 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.