NTRC 0066-0

Cat. No.: HY-100024 Purity: 99.01%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC₅₀=0.9 nM). NTRC 0066-0 can be used for the research of cancer.

For research use only. We do not sell to patients.

NTRC 0066-0 Chemical Structure

CAS No. : 1817791-73-3

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 224	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 224	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Description

NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC₅₀=0.9 nM). NTRC 0066-0 can be used for the research of cancer^[1].

IC₅₀ & Target

IC50: 0.9 nM (TTK)^[1]

In Vitro

NTRC 0066-0 has a low selectivity entropy and a relatively long target residence time on TTK and inhibits the proliferation of diverse cancer cell lines with a potency in the same range as that of classic chemotherapeutic agents such as doxorubicin. NTRC 0066-0, has subnanomolar potency in a TTK enzyme assay and inhibits the proliferation of cancer cell lines from diverse tumor tissue origin with IC₅₀ from 11 to 290 nM at 5-day incubation time^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NTRC 0066-0 inhibited tumor growth in a mouse xenograft model of the human triple-negative breast cancer (TNBC) cell line MDA-MB-231^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

565.71

Formula

C₃₃H₃₉N₇O₂

CAS No.

1817791-73-3

Appearance

Solid

Color

White to yellow

SMILES

O=C(C1=C2CCC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=C4OC)N=C3N2C=C1)NC6=C(CC)C=CC=C6CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20.83 mg/mL (36.82 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7677 mL	8.8385 mL	17.6769 mL
5 mM	0.3535 mL	1.7677 mL	3.5354 mL
10 mM	0.1768 mL	0.8838 mL	1.7677 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.01%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (248 KB) HNMR (141 KB) RP-HPLC (168 KB) LCMS (231 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7677 mL	8.8385 mL	17.6769 mL	44.1923 mL
	5 mM	0.3535 mL	1.7677 mL	3.5354 mL	8.8385 mL
	10 mM	0.1768 mL	0.8838 mL	1.7677 mL	4.4192 mL
	15 mM	0.1178 mL	0.5892 mL	1.1785 mL	2.9462 mL
	20 mM	0.0884 mL	0.4419 mL	0.8838 mL	2.2096 mL
	25 mM	0.0707 mL	0.3535 mL	0.7071 mL	1.7677 mL
	30 mM	0.0589 mL	0.2946 mL	0.5892 mL	1.4731 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NTRC 0066-01817791-73-3Inhibitorinhibitorinhibit

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