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Art. -Nr.: HY-132884

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TTK inhibitor 3

TTK inhibitor 3 is a potent and selective TTK (an essential spindle assembly checkpoint enzyme) inhibitor with an IC₅₀ value of 3.0 nM.

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CAS. Nr.: 2820453-41-4
Formel: C₄₂H₄₉N₉O₃
Molecular Weight:727.90

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

TTK inhibitor 3 Chemical Structure

CAS. Nr.: 2820453-41-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

TTK inhibitor 3 is a potent and selective TTK (an essential spindle assembly checkpoint enzyme) inhibitor with an IC₅₀ value of 3.0 nM.

Cellular Effect

Cell Line	Type	Value	Description	References
CAL-51	IC₅₀	0.016 μM Compound: 25	Antiproliferative activity against human CAL-51 cells assessed as inhibition of cell proliferation measured after 3 days by Cell Titer-Glo luminescence based assay Antiproliferative activity against human CAL-51 cells assessed as inhibition of cell proliferation measured after 3 days by Cell Titer-Glo luminescence based assay	[PMID: 34459599]

Chemical Information

CAS. Nr. 2820453-41-4
Molecular Weight 727.90
Formel C₄₂H₄₉N₉O₃
SMILES

O=C1C2=CC(C3=C4C(NC=C4)=NC(NC5=CC=C(N6CCC(C(N7CC8(CN(C)C8)C7)=O)CC6)C=C5OC)=N3)=CN2CCN1C9=C(CC)C=CC=C9CC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Elsner J, et al. Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity. J Med Chem. 2021 Sep 9;64(17):12670-12679. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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