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Cat. No.: HY-132884

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TTK inhibitor 3

TTK inhibitor 3 is a potent and selective TTK (an essential spindle assembly checkpoint enzyme) inhibitor with an IC₅₀ value of 3.0 nM.

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CAS No.: 2820453-41-4
Formule: C₄₂H₄₉N₉O₃
Masse moléculaire:727.90

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

TTK inhibitor 3 Chemical Structure

CAS No.: 2820453-41-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

TTK inhibitor 3 is a potent and selective TTK (an essential spindle assembly checkpoint enzyme) inhibitor with an IC₅₀ value of 3.0 nM.

Cellular Effect

Cell Line	Type	Value	Description	References
CAL-51	IC₅₀	0.016 μM Compound: 25	Antiproliferative activity against human CAL-51 cells assessed as inhibition of cell proliferation measured after 3 days by Cell Titer-Glo luminescence based assay Antiproliferative activity against human CAL-51 cells assessed as inhibition of cell proliferation measured after 3 days by Cell Titer-Glo luminescence based assay	[PMID: 34459599]

Chemical Information

CAS No. 2820453-41-4
Masse moléculaire 727.90
Formule C₄₂H₄₉N₉O₃
SMILES

O=C1C2=CC(C3=C4C(NC=C4)=NC(NC5=CC=C(N6CCC(C(N7CC8(CN(C)C8)C7)=O)CC6)C=C5OC)=N3)=CN2CCN1C9=C(CC)C=CC=C9CC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Elsner J, et al. Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity. J Med Chem. 2021 Sep 9;64(17):12670-12679. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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