2. Cell Cycle/DNA Damage Cytoskeleton
  3. Mps1
  4. Mps1-IN-6

Mps1-IN-6 is a potent Mps1 inhibitor with an IC50 value of 2.596 nM. Mps1-IN-6 shows antiproliferative activity. Mps1-IN-6 shows antitumor activity.

For research use only. We do not sell to patients.

Mps1-IN-6 Chemical Structure

Mps1-IN-6 Chemical Structure

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Mps1-IN-6 Related Antibodies

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Description

Mps1-IN-6 is a potent Mps1 inhibitor with an IC50 value of 2.596 nM. Mps1-IN-6 shows antiproliferative activity. Mps1-IN-6 shows antitumor activity[1].

IC50 & Target

IC50: 2.596 nM (Mps1)[1]
In Vitro

Mps1-IN-6 (compound 31) (0-10 µM; 72 h) shows antiproliferative activity with IC50s of 0.221, >10, >10, 0.823, >10 µM for MDA-MB-468, MCF-7, REB, MV4-11, HT-29 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mps1-IN-6 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MDA-MB-468, MCF-7, REB, MV4-11, HT-29 cells
Concentration: 0-10 µM
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50s of 0.221, >10, >10, 0.823, >10 µM for MDA-MB-468, MCF-7, REB, MV4-11, HT-29 cells, respectively.
In Vivo

Mps1-IN-6 (30, 60 mg/kg; i.v.; once daily for 21 days) shows antitumor activity in mice[1].
Pharmacokinetic Parameters of Mps1-IN-6 in Male Sprague-Dawley rats[1].

parameters (unit) iv (2 mg/kg) po (10 mg/kg)
C0 (ng/mL) 5237 -
Cmax (ng/mL) 2920 160
T1/2 (h) 0.825 1.05
Tmax (h) 0.083 0.333
AUC(0-t) (h*ng/mL) 1050 204
AUC(0-∞) (h*ng/mL) 1052 208
MRT(0-t) (h) 0.34 1.11
MRT(0-∞) (h) 0.354 1.23
CL (mL/kg/min) 32 -
Vss (L/kg) 0.672 -
F % - 3.95
Male Sprague-Dawley rats, 2 mg/kg iv; 10 mg/kg po.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six to eight week-old female BALB/c nude mice (MDA-MB-468 mouse xenograft model)[1]
Dosage: 30, 60 mg/kg
Administration: I.v.; once daily for 21 days
Result: Inhibited the tumor growth with TGI values of 21%, 34% for 30, 60 mg/kg, respectively.
Molecular Weight

633.74

Formula

C35H39N9O3
SMILES

CCC1=CC=CC(CC)=C1N2CCN3C=C(C=C3C2=O)C4=C5C=NNC5=NC(NC6=C(C=C(C=C6)N7CCN(CC7)C(C)=O)OC)=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Mps1-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mps1-IN-6Mps1Monopolar spindle 1antiproliferativeantitumorMDA-MB-468 cellsInhibitorinhibitorinhibit

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