UbcH6/UBE2E1 Protein, Human (Sf9)

The UbcH6/UBE2E1 protein is an important ubiquitination component that acts as an E2 ubiquitin-conjugating enzyme, accepting ubiquitin in the E1 complex and catalyzing its covalent attachment to proteins. It is versatile and also facilitates covalent attachment of ISG15, playing a role in a variety of ubiquitin-like modifications. UbcH6/UBE2E1 Protein, Human (Sf9) is the recombinant human-derived UbcH6/UBE2E1 protein, expressed by Sf9 insect cells , with tag free. The total length of UbcH6/UBE2E1 Protein, Human (Sf9) is 192 a.a., .

UbcH6/UBE2E1, a pivotal component of the ubiquitination machinery, functions as an E2 ubiquitin-conjugating enzyme by accepting ubiquitin from the E1 complex and catalyzing its covalent attachment to other proteins. Notably versatile, this enzyme also facilitates the covalent attachment of ISG15 to other proteins, highlighting its role in diverse ubiquitin-like modifications. Beyond conventional ubiquitination, UbcH6/UBE2E1 plays a crucial role in the selective degradation of short-lived and abnormal proteins, contributing to cellular quality control mechanisms. Furthermore, in vitro studies demonstrate its ability to catalyze 'Lys-48'-linked polyubiquitination, underscoring its involvement in the regulation of protein stability and turnover.

Human

Sf9 insect cells

Tag Free

P51965 (S2-T193)

7324

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.