PAK Inhibitor

PAK Inhibitors (34):

Cat. No.	Product Name	Effect	Purity

HY-15027

5-Aminosalicylic Acid	Inhibitor	≥98.0%
5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-13007

PF-3758309	Inhibitor	99.84%
PF-3758309 (PF-03758309) is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (K_d= 2.7 nM; K_i=18.7 nM). PF-3758309 has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation.

HY-15663

IPA-3	Inhibitor	99.43%
IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC₅₀ of 2.5 μM, and shows no inhibition to group II PAKs (PAKs 4-6).

HY-P10106

TAT-PAK18 inhibitory peptide	Inhibitor
TAT-PAK18 inhibitory peptide is a membrane-permeable PAK inhibitory peptide. TAT-PAK18 inhibitory peptide reduces F-actin clusters and occludes the effect of Shank3 knockdown.

HY-156453

PAK4-IN-3	Inhibitor
PAK4-IN-3(compound 27e) is aPAK4inhibitor, with theIC₅₀of 10 nM.PAK4-IN-3shows antiproliferative activity against A549 cells with anIC₅₀value of 0.61μM, and inducesapoptosisof A549 cells in a concentration-dependent manner and blocked the cell cycle at phase G0/G1.

HY-100519

NVS-PAK1-1	Inhibitor	99.50%
NVS-PAK1-1 is a potent and selective allosteric PAK1 inhibitor with an IC₅₀ of 5 nM.

HY-15542A

FRAX597	Inhibitor	99.79%
FRAX597 is a potent group I p21-activated Kinases (PAKs) inhibitor with IC₅₀ of 8, 13 and 19 nM for PAK1, 2 and 3.

HY-15542B

FRAX486	Inhibitor	98.01%
FRAX486 is a p21-activated kinase (PAK) inhibitor with IC₅₀s of 14, 33 and 39 nM for PAK1, PAK2 and PAK3, respectively.

HY-19635

G-5555	Inhibitor	99.29%
G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with K_is of 3.7 nM and 11 nM for PAK1 and PAK2, respectively.

HY-12632

GNE 2861	Inhibitor	99.47%
GNE 2861 is a PAK inhibitor that displays group II selectivity. GNE 2861 inhibits PAK4, PAK5 and PAK6 with IC₅₀s of 7.5, 36, 126 nM, respectively.

HY-19538

FRAX1036	Inhibitor	98.88%
FRAX1036 is a PAK inhibitor with K_is of 23.3 nM, 72.4 nM, and 2.4 μM for PAK1, PAK2 and PAK4, respectively.

HY-12793

Padnarsertib	Inhibitor	99.86%
Padnarsertib (KPT-9274) is an orally bioavailable, dual PAK4/Nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with IC₅₀s of <100 nM and 120 nM, respectively.

HY-125035

LCH-7749944	Inhibitor	99.36%
LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC₅₀ of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis.

HY-19635A

G-5555 hydrochloride	Inhibitor	98.78%
G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a K_i of 3.7 nM.

HY-139253

MRIA9	Inhibitor	98.34%
MRIA9 is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC₅₀ values of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3, respectively.

HY-120940

AZ13705339	Inhibitor	98.90%
AZ13705339 is a highly potent and selective PAK1 inhibitor with IC₅₀s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 has binding affinities to PAK1 and PAK2, with K_ds of 0.28 nM and 0.32 nM, respectively. AZ13705339 can be used in the research of cancers.

HY-120940A

AZ13705339 hemihydrate	Inhibitor	99.77%
AZ13705339 hemihydrate is a highly potent and selective PAK1 inhibitor with IC₅₀s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities to PAK1 and PAK2, with K_ds of 0.28 nM and 0.32 nM, respectively. AZ13705339 hemihydrate can be used in the research of cancers.

HY-143490

PAK4-IN-2	Inhibitor	99.78%
PAK4-IN-2 is a highly potent PAK4 inhibitor with IC₅₀ value of 2.7 nM. PAK4-IN-2 can arrest MV4-11 cells at G0/G1 phase and induce cell apoptosis. PAK4-IN-2 can be used for researching cancer.

HY-146681

PAK1-IN-1	Inhibitor
PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC₅₀ of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner.

HY-155179

ZMF-23	Inhibitor
ZMF-23 is a PAK1/HDAC6 dual inhibitor. ZMF-23 inhibits PAK1 and HDAC6 regulated aerobic glycolysis and migration. ZMF-23 induces TNF-α-regulated necroptosis, and further enhances apoptosis. ZMF-23 inhibits the Warburg effect and cell migration. ZMF-23 can be used for research of triple-negative breast cancer (TNBC).

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