796888-12-5
796888-12-5
Chemical Structure
LCH-7749944
Synonym(s): GNF-PF-2356
- CAS No.: 796888-12-5
- Formula:C20H22N4O2
- Molecular Weight:350.41
IUPAC Name: N2-(3-methoxyphenyl)-N4-((tetrahydrofuran-2-yl)methyl)quinazoline-2,4-diamine
InChIKey: FBWZAFQEOKNGQL-UHFFFAOYSA-N
SMILES: COC1=CC(NC2=NC(NCC3OCCC3)=C4C=CC=CC4=N2)=CC=C1
Biological Activity: LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis[1].
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LCH-7749944 | 99.68% | LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. | ||||||||||||||||||||
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