PP487
PP487 is a selective dual inhibitor of Tyrosine kinase/PI3-K, with IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. PP487 can be used in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1092787-12-6
- Formula: C14H14BrN5O
- Molecular Weight:348.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
p110α 0.046 μM (IC50) |
p110β 0.24 μM (IC50) |
p110δ 0.027 μM (IC50) |
p110γ 0.1 μM (IC50) |
Abl 0.021 μM (IC50) |
VEGFR2 0.055 μM (IC50) |
PP487 (0.001-50 µM) potently inhibits nanomolar-concentration tyrosine kinases (including Src) as well as members of the PI3-K family (including mTOR), while maintaining high selectivity toward the serine-threonine kinase panel[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1092787-12-6
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Molecular Weight 348.20
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Formula C14H14BrN5O
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SMILES
BrC1=C(O)C=C(C2=NN(C(C)C)C3=C2C(N)=NC=N3)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PP487 Related Classifications
HY-15268 Related Classifications
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