PP487
PP487 is a selective dual inhibitor of Tyrosine kinase/PI3-K, with IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. PP487 can be used in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1092787-12-6
- Formula: C14H14BrN5O
- Molecular Weight:348.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
p110α 0.046 μM (IC50) |
p110β 0.24 μM (IC50) |
p110δ 0.027 μM (IC50) |
p110γ 0.1 μM (IC50) |
Abl 0.021 μM (IC50) |
VEGFR2 0.055 μM (IC50) |
In Vitro
PP487 (0.001-50 µM) potently inhibits nanomolar-concentration tyrosine kinases (including Src) as well as members of the PI3-K family (including mTOR), while maintaining high selectivity toward the serine-threonine kinase panel[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1092787-12-6
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Molecular Weight 348.20
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Formula C14H14BrN5O
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SMILES
BrC1=C(O)C=C(C2=NN(C(C)C)C3=C2C(N)=NC=N3)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PP487 Related Classifications
HY-15268 Related Classifications
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