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Cat. No.: HY-15268

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PP487

PP487 is a selective dual inhibitor of Tyrosine kinase/PI3-K, with IC₅₀ values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. PP487 can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 1092787-12-6
Formula: C₁₄H₁₄BrN₅O
Molecular Weight:348.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PP487 Chemical Structure

CAS No.: 1092787-12-6

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

p110α

0.046 μM (IC₅₀)

p110β

0.24 μM (IC₅₀)

p110δ

0.027 μM (IC₅₀)

p110γ

0.1 μM (IC₅₀)

Abl

0.021 μM (IC₅₀)

VEGFR2

0.055 μM (IC₅₀)

All PI3K Isoforms :

All mTOR Isoforms :

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

All Src Isoforms :

All VEGFR Isoforms :

All EGFR Isoforms :

All PDGFR Isoforms :

In Vitro

PP487 (0.001-50 µM) potently inhibits nanomolar-concentration tyrosine kinases (including Src) as well as members of the PI3-K family (including mTOR), while maintaining high selectivity toward the serine-threonine kinase panel^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1092787-12-6
Molecular Weight 348.20
Formula C₁₄H₁₄BrN₅O
SMILES

BrC1=C(O)C=C(C2=NN(C(C)C)C3=C2C(N)=NC=N3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Apsel B, et al. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008;4(11):691-699. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PP487

All PI3K Isoforms

All mTOR Isoforms

All Bcr-Abl Isoforms

All Src Isoforms

All VEGFR Isoforms

All EGFR Isoforms

All PDGFR Isoforms