2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Cell Cycle/DNA Damage JAK/STAT Signaling
  3. c-Met/HGFR PI3K DNA-PK mTOR Bcr-Abl Src VEGFR EGFR PDGFR
  4. PP487

PP487 is a selective dual inhibitor of Tyrosine kinase/PI3-K, with IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. PP487 can be used in cancer research.

For research use only. We do not sell to patients.

PP487

PP487 Chemical Structure

CAS No. : 1092787-12-6

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PP487 Related Antibodies

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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mTOR mTORC1 mTORC2

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Abl Bcr-Abl

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Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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PDGFR PDGFRβ PDGFRα

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Description

PP487 is a selective dual inhibitor of Tyrosine kinase/PI3-K, with IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. PP487 can be used in cancer research[1].

IC50 & Target[1]

p110α

0.046 μM (IC50)

p110β

0.24 μM (IC50)

p110δ

0.027 μM (IC50)

p110γ

0.1 μM (IC50)

Abl

0.021 μM (IC50)

VEGFR2

0.055 μM (IC50)

In Vitro

PP487 (0.001-50 µM) potently inhibits nanomolar-concentration tyrosine kinases (including Src) as well as members of the PI3-K family (including mTOR), while maintaining high selectivity toward the serine-threonine kinase panel[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PP487 Related Antibodies
Molecular Weight

348.20

Formula

C14H14BrN5O
CAS No.
SMILES

BrC1=C(O)C=C(C2=NN(C(C)C)C3=C2C(N)=NC=N3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PP487 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PP4871092787-12-6PP 487PP-487c-Met/HGFRPI3KDNA-PKmTORBcr-AblSrcVEGFREGFRPDGFRPhosphoinositide 3-kinaseDNA-dependent protein kinaseMammalian target of RapamycinVascular endothelial growth factor receptorEpidermal growth factor receptorErbB-1HER1Platelet-derived growth factor receptorAblserine-threonine kinomeVEGF receptorp110αPI3-K family memberstyrosine kinasesInhibitorinhibitorinhibit

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