2191110-79-7
Chemical Structure
EN171
- CAS No.: 2191110-79-7
- Formula:C17H22N2O
- Molecular Weight:270.37
InChIKey: VKQVCQHCQMFBNJ-UHFFFAOYSA-N
SMILES: O=C(N1CCC2(CN(CC2)CC3=CC=CC=C3)C1)C=C
Biological Activity: EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EN171 | 98.14% | EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol. | ||||||||||||||||||||
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Keywords
