14-3-3 Protein
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14-3-3 Protein Related Products (4)
Related Products (4)
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GR–14-3-3 stabilizer-1
0 ImagesGR-14-3-3 stabilizer-1 is a molecular glue stabilizer for the protein-protein interaction between 14‑3‑3 and glucocorticoid receptor (GR), and functions by stabilizing the GR‑14‑3‑3 protein-protein interaction. GR-14-3-3 stabilizer-1 is applicable to research related to diseases such as tumors.
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PAV-104
0 ImagesSynonyms: MAV-104PAV-104 (MAV-104) is a host-targeted, pan-respiratory viral assembly inhibitor. PAV-104 targets a small subset of the host protein 14-3-3 within a transient multi-protein complex. PAV-104 inhibits SARS-CoV-2 replication by blocking post-entry viral assembly/budding through interaction with viral nucleocapsid (N) protein and interference with its oligomerization. PAV-104 is orally active in cats and shows favorable pharmacokinetic properties in rats. PAV-104 can be used for the study of COVID-19 and other respiratory viral infections, including Feline Infectious Peritonitis (FIP).
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ChREBPα/14-3-3 regulator-1
0 ImagesCat. No.: HY-170593CAS No.: 3067202-14-3ChREBPα/14-3-3 regulator-1 is a molecular glue that selectively stabilizes ChREBPα/14-3-3 PPI, with an EC50 of 3.8 μM. ChREBPα/14-3-3 regulator-1 sequesters ChREBPα in the cytoplasm, inhibits ChREBPβ and TXNIP responses, reduces glucolipotoxicity-induced β-cell death, and maintains β-cell identity and function. ChREBPα/14-3-3 regulator-1 can be used in studies related to type 2 diabetes.
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EN171
0 ImagesEN171 is a covalent 14-3-3σ molecular glue ligand that sequesters neonuclear substrates, including BRD4 and BLC6, into the cytoplasm by recruiting 14-3-3σ. EN171 covalently targets C38 and C96 on 14-3-3 to enhance the interaction between 14-3-3 and ERα, YAP, and TAZ (with EC50 values of 9 μM for human ERα, 45 μM for YAP, and 107 μM for TAZ). EN171 inhibits the transcriptional activity of estrogen receptors and the Hippo pathway in breast cancer cells. EN171 can be used in studies related to breast cancer.
