2. Signaling Pathways
  3. Apoptosis
    Autophagy
  4. 14-3-3 Protein
  5. 14-3-3 Protein Inducer

14-3-3 Protein Inducer

14-3-3 Protein Isoform Comparison

14-3-3 Protein Inducers (3):

Cat. No. Product Name Effect Purity
  • HY-N13798
    ADHPE
    		Inducer
    ADHPE is a stabilizer of 14-3-3σ and p65 protein complex. ADHPE inhibits NF-κB (p65) signaling pathway and reduces the inflammatory response. ADHPE can be used for pediatric pneumonia-related acute lung injury and acute respiratory distress syndrome study.
  • HY-162838
    TCF199
    		Inducer
    TCF199 is an allosteric stabilizer that stabilizes the 14-3-3/TAZ peptide interaction, binding to the 14-3-3ζ/E R α peptide and 14-3-3ζ/Chibby peptide. TCF199 has a Kd value of 122 μM for its interaction with 14-3-3/TAZ.
  • HY-175872
    14-3-3σ/ERα stabilizer-2
    		Inducer
    14-3-3σ/ERα stabilizer-2 (Compound 41) is a covalent 14-3-3σ/ERα stabilizer with a Kd of 10.1 nM. 14-3-3σ/ERα stabilizer-2 significantly decreases the dissociation rate of ERα, stabilizing the binary ERα/14-3-3σ interaction. 14-3-3σ/ERα stabilizer-2 can be used for molecular glues research.