14-3-3σ/ERα stabilizer-2
14-3-3σ/ERα stabilizer-2 (Compound 41) is a covalent 14-3-3σ/ERα stabilizer with a Kd of 10.1 nM. 14-3-3σ/ERα stabilizer-2 significantly decreases the dissociation rate of ERα, stabilizing the binary ERα/14-3-3σ interaction. 14-3-3σ/ERα stabilizer-2 can be used for molecular glues research.
For research use only. We do not sell to patients.
- Formula: C24H22ClFN4O
- Molecular Weight:436.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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14-3-3σ |
Chemical Information
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Molecular Weight 436.91
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Formula C24H22ClFN4O
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SMILES
CC1=C(NC2=C(C3=CC=C(NC(CCl)=O)C=C3F)N=C4N2C=C(C)C=C4)C(C)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)