2. Vitamin D Related/Nuclear Receptor PI3K/Akt/mTOR Immunology/Inflammation Apoptosis
  3. Estrogen Receptor/ERR Akt MELK COX Apoptosis
  4. Moracin G

Moracin G is a plant-derived kinase modulator and receptor ligand that forms stable bindings with multiple key proteins (AKT1, COX2 and Estrogen receptor 1) and competitively inhibits the activity of specific kinases. By binding to MELK to disrupt cell cycle regulation, Moracin G impairs the survival and proliferation of cancer cells, induces cancer cell apoptosis, and thereby exerts anti-tumor potential. Moracin G can be used in research related to periodontitis and breast cancer.

For research use only. We do not sell to patients.

Moracin G

Moracin G Chemical Structure

CAS No. : 73338-86-0

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Moracin G Related Antibodies

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Akt Akt1 Akt2 Akt3

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COX COX-1 COX-2 COX-3

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Description

Moracin G is a plant-derived kinase modulator and receptor ligand that forms stable bindings with multiple key proteins (AKT1, COX2 and Estrogen receptor 1) and competitively inhibits the activity of specific kinases. By binding to MELK to disrupt cell cycle regulation, Moracin G impairs the survival and proliferation of cancer cells, induces cancer cell apoptosis, and thereby exerts anti-tumor potential. Moracin G can be used in research related to periodontitis and breast cancer[1][2].

IC50 & Target

Akt1

 

COX-2

 

In Vitro

Moracin G meets the pharmacokinetic criteria for active ingredients, with an oral bioavailability of 75.78% and a drug-likeness score of 0.42[1].
Moracin G is a key active component in mulberry leaves that alleviates periodontitis, and it interacts with 37 different human targets associated with periodontitis. The top 10 key targets are IL-6, ALB, TNF, VEGFA, AKT1, TP53, PTGS2, EGF, MMP9, and IL-10, among which the binding affinity with AKT1 is -10.7 kcal/mol[1].
Moracin G exhibits favorable in silico ADMET properties, including high gastrointestinal absorption, low blood-brain barrier permeability, and no predicted toxicity, rendering it a viable candidate for further development[2].

Moracin G is predicted to have a high probability of acting as a kinase inhibitor, antineoplastic agent, apoptosis agonist, and antineoplastic agent against breast cancer[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Moracin G Related Antibodies
Molecular Weight

308.33

Formula

C19H16O4
CAS No.
SMILES

OC1=CC(O)=CC(C2=CC(C=CC3=C4CC=C(C)CO3)=C4O2)=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Moracin G Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Moracin G73338-86-0Estrogen Receptor/ERRAktMELKCOXApoptosisPKBProtein kinase BMaternal embryonic leucine zipper kinaseCyclooxygenaseAKT1Estrogen receptor 1RAC-alpha serine/threonine-protein kinasePTGS2Prostaglandin G/H synthase 2ESR1breast cancerperiodontitisapoptosisInhibitorinhibitorinhibit

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