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Results for "

MELK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MELK (8) Apoptosis (6) CDK (2) Checkpoint Kinase (Chk) (5) DNA/RNA Synthesis (1) DYRK (2) FLT3 (2) GSK-3 (2) mTOR (2) Pim (2) PROTACs (1) RIP kinase (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (15)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: MELK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100368A

MELK-8a hydrochloride 3 Publications Verification NVS-MELK8a hydrochloride	MELK	Cancer
MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor with an IC₅₀ of 2 nM.

HY-101515

MELK-IN-1

MELK Cancer

MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC₅₀ and a K_i of 3 nM and 0.39 nM, respectively.

MELK-IN-1	MELK	Cancer
MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC₅₀ and a K_i of 3 nM and 0.39 nM, respectively.

HY-100368

MELK-8a NVS-MELK8a
MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC₅₀ of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC₅₀s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells .

HY-RS08328

MELK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MELK Human Pre-designed siRNA Set A contains three designed siRNAs for MELK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MELK Human Pre-designed siRNA Set A MELK Human Pre-designed siRNA Set A

HY-RS08329

Melk Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Melk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Melk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Melk Mouse Pre-designed siRNA Set A Melk Mouse Pre-designed siRNA Set A

HY-RS08330

Melk Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Melk Rat Pre-designed siRNA Set A contains three designed siRNAs for Melk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Melk Rat Pre-designed siRNA Set A Melk Rat Pre-designed siRNA Set A

HY-12420

JNJ-47117096 hydrochloride MELK-T1 hydrochloride	MELK FLT3	Cancer
JNJ-47117096 hydrochloride is potent and selective *MELK* inhibitor, with an IC₅₀ of 23 nM, also effectively inhibits Flt3, with an IC₅₀ of 18 nM.

HY-155748

Antitumor agent-116	MELK Apoptosis	Cancer
Antitumor agent-116 (compound 6C) is an anti-tumor agent with anti-proliferative activities. Antitumor agent-11 induces cell apoptosis, and shows the binding affinity against the MELK receptor .

HY-15512A

OTSSP167 hydrochloride Maximum Cited Publications 17 Publications Verification OTS167 hydrochloride	MELK	Cancer
OTSSP167 (OTS167) hydrochloride is a highly potent and ATP-competitive *MELK* inhibitor with IC₅₀ value of 0.41 nM.

HY-15512

OTSSP167 Maximum Cited Publications 17 Publications Verification OTS167	MELK	Cancer
OTSSP167 (OTS167) is a highly potent and ATP-competitive *MELK* inhibitor with IC₅₀ value of 0.41 nM.

HY-144869

OTS447

FLT3 Cancer

OTS447 is a potent FLT3 inhibitor with an IC₅₀ of 21 nM (WO2012016082A1, compound 335) .

OTS447	FLT3	Cancer
OTS447 is a potent FLT3 inhibitor with an IC₅₀ of 21 nM (WO2012016082A1, compound 335) .

HY-122665

HTH-01-091	MELK DYRK Pim mTOR CDK GSK-3 RIP kinase	Cancer
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC₅₀ of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be uesd for breast cancer research .

HY-122665A

HTH-01-091 TFA	MELK DYRK Pim mTOR CDK GSK-3 RIP kinase	Cancer
HTH-01-091 TFA is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC₅₀ of 10.5 nM. HTH-01-091 TFA also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 TFA can be uesd for breast cancer research .

HY-148065

FMF-06-098-1	PROTACs	Cancer
FMF-06-098-1 is a multitargeted depressant. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 .

HY-18174

Prexasertib Maximum Cited Publications 17 Publications Verification LY2606368	Checkpoint Kinase (Chk) Apoptosis	Cancer
Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity .

HY-18174A

Prexasertib dihydrochloride Maximum Cited Publications 17 Publications Verification LY2606368 dihydrochloride	Checkpoint Kinase (Chk) Apoptosis	Cancer
Prexasertib dihydrochloride (LY2606368 dihydrochloride) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib dihydrochloride inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib dihydrochloride causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dihydrochloride shows potent anti-tumor activity .

HY-18174E

Prexasertib dimesylate Maximum Cited Publications 17 Publications Verification LY2606368 dimesylate	Checkpoint Kinase (Chk) Apoptosis	Cancer
Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib dimesylate inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib dimesylate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dimesylate shows potent anti-tumor activity .

HY-18174B

Prexasertib Mesylate Hydrate LY2606368 Mesylate Hydrate; LY2940930	Checkpoint Kinase (Chk) Apoptosis	Cancer
Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib Mesylate Hydrate inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib Mesylate Hydrate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib Mesylate Hydrate shows potent anti-tumor activity .

HY-18174C

Prexasertib mesylate LY2606368 mesylate	Checkpoint Kinase (Chk) DNA/RNA Synthesis Apoptosis	Cancer
Prexasertib mesylate (LY2606368 mesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib mesylate inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib mesylate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib mesylate shows potent anti-tumor activity .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701811

	MELK Protein, Human (His) MELK; Maternal embryonic leucine zipper kinase; hMELK; Protein kinase Eg3; pEg3 kinase; Protein kinase PK38; hPK38; Tyrosine-protein kinase MELK	Human	E. coli
	MELK is a multifunctional serine/threonine protein kinase that regulates the cell cycle, stem cell self-renewal, apoptosis, and splicing. MELK phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622, activates apoptosis through MAP3K5/ASK1, helps CDC25B localize during mitosis, and inhibits BCL2L14, which may affect breast cancer occurrence. MELK Protein, Human (His) is the recombinant human-derived MELK protein, expressed by E. coli , with N-6*His labeled tag. The total length of MELK Protein, Human (His) is 328 a.a., .

HY-P701810

	MELK Protein, Human MELK; Maternal embryonic leucine zipper kinase; hMELK; Protein kinase Eg3; pEg3 kinase; Protein kinase PK38; hPK38; Tyrosine-protein kinase MELK	Human	E. coli
	MELK is a multifunctional serine/threonine protein kinase that regulates the cell cycle, stem cell self-renewal, apoptosis, and splicing. MELK phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622, activates apoptosis through MAP3K5/ASK1, helps CDC25B localize during mitosis, and inhibits BCL2L14, which may affect breast cancer occurrence. MELK Protein, Human is the recombinant human-derived MELK protein, expressed by E. coli , with tag free. The total length of MELK Protein, Human is 328 a.a., .


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