109944-15-2
109944-15-2
Chemical Structure
Kifunensine
Synonym(s): FR-900494
- CAS No.: 109944-15-2
- Formula:C8H12N2O6
- Molecular Weight:232.19
IUPAC Name: (5R,6R,7S,8R,8aS)-6,7,8-trihydroxy-5-(hydroxymethyl)hexahydroimidazo[1,2-a]pyridine-2,3-dione
InChIKey: OIURYJWYVIAOCW-PQMKYFCFSA-N
SMILES: O=C(N1[C@@](N2)([H])[C@@H](O)[C@@H](O)[C@H](O)[C@H]1CO)C2=O
Biological Activity: Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD[1][2][3].
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Kifunensine | 99.90% | Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD. | ||||||||||||||||||||
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Kifunensine (Standard) | ≥98% | Bromperidol decanoate (Standard) is the analytical standard of Bromperidol decanoate. This product is intended for research and analytical applications. Bromperidol decanoate (R46541) is a compound used for the inhibition of schizophrenia and has certain clinical inhibitory activity. | ||||||||||||||||||||
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References
- [1]. Yongao Xiong, et al. Glycoform Modification of Secreted Recombinant Glycoproteins through Kifunensine Addition during Transient Vacuum Agroinfiltration. Int J Mol Sci. 2018 Mar; 19(3): 890.
- [2]. Hiroshi Kayakiri, et al. Structure of Kifunensine, a New Immunomodulator Isolated from an Actinomycete. J. Org. Chem. 1989,54,4015-4016.
- [3]. Qun Zhou, et al. Development of a Simple and Rapid Method for Producing Non-Fucosylated Oligomannose Containing Antibodies With Increased Effector Function. Biotechnol Bioeng. 2008 Feb 15;99(3):652-65. [Content Brief]
Keywords
