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  5. Kifunensine

Kifunensine  (Synonyms: FR-900494)

Cat. No.: HY-19332 Purity: 99.30%
COA Handling Instructions

Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD.

For research use only. We do not sell to patients.

Kifunensine Chemical Structure

Kifunensine Chemical Structure

CAS No. : 109944-15-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 330 In-stock
Solution
10 mM * 1 mL in DMSO USD 330 In-stock
Solid
5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 960 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Kifunensine Related Antibodies

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Description

Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD[1][2][3].

In Vitro

Kifunensine, an alkaloid from actinomycete Kitasatosporia kifunense 9482, is the most efficient nhibitor of a-mannosidase I, blocking N-glycan synthesis at an8GlcNAc2 (Man8) or Man9GlcNAc2 (Man9) stage[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kifunensine Related Antibodies

RT-PCR[3].

Cell Line: Hybridoma cells expressing a human IgG1 monoclonal Antibody[3].
Concentration: 2 μg/mL.
Incubation Time: 4 days.
Result: Significantly reduced the lentil lectin binding.
Kifunensine is the most effective among the inhibitors tested in producing antibodies containing oligomannose residues without fucose.
In Vivo
Animal Model: BALB/c mice[3].
Dosage: 5 mg/kg.
Administration: IV via tail vein.
Result: There was no significant difference in the serum levels of anti-TEM B mAb generated from cells treated with or without kifunensine in the 7-day period.
Molecular Weight

232.19

Appearance

Solid

Formula

C8H12N2O6
CAS No.
SMILES

O=C(N1[C@@](N2)([H])[C@@H](O)[C@@H](O)[C@H](O)[C@H]1CO)C2=O
Structure Classification
Initial Source

actinomycete
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 11.9 mg/mL (51.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3068 mL 21.5341 mL 43.0682 mL
5 mM 0.8614 mL 4.3068 mL 8.6136 mL
10 mM 0.4307 mL 2.1534 mL 4.3068 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.19 mg/mL (5.13 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1.19 mg/mL (5.13 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 1.19 mg/mL (5.13 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.87%

COA (257 KB) HNMR (264 KB) RP-HPLC (246 KB) MS (182 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Kifunensine109944-15-2FR-900494FR900494FR 900494OthersERADER StressInhibitorinhibitorinhibit

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