1. Alkaloids
  2. Kifunensine

Kifunensine (Synonyms: FR-900494)

Cat. No.: HY-19332
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Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD.

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Kifunensine Chemical Structure

Kifunensine Chemical Structure

CAS No. : 109944-15-2

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Description

Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD[1][2][3].

In Vitro

Kifunensine, an alkaloid from actinomycete Kitasatosporia kifunense 9482, is the most efficient nhibitor of a-mannosidase I, blocking N-glycan synthesis at an8GlcNAc2 (Man8) or Man9GlcNAc2 (Man9) stage[3].

RT-PCR[3].

Cell Line: Hybridoma cells expressing a human IgG1 monoclonal Antibody[3].
Concentration: 2 μg/mL.
Incubation Time: 4 days.
Result: Significantly reduced the lentil lectin binding.
Kifunensine is the most effective among the inhibitors tested in producing antibodies containing oligomannose residues without fucose.
In Vivo
Animal Model: BALB/c mice[3].
Dosage: 5 mg/kg.
Administration: IV via tail vein.
Result: There was no significant difference in the serum levels of anti-TEM B mAb generated from cells treated with or without kifunensine in the 7-day period.
Molecular Weight

232.19

Formula

C₈H₁₂N₂O₆

CAS No.

109944-15-2

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

KifunensineFR-900494FR900494FR 900494OthersERADER StressInhibitorinhibitorinhibit

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