Phosphatase
Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.
All Product Categories
-
Phosphatase Inhibitors
(513)
View all products
-
Phosphatase Agonists
(4)
View all products
-
Phosphatase Antagonists
(4)
View all products
-
Phosphatase Activators
(78)
View all products
-
Phosphatase Modulators
(7)
View all products
-
Phosphatase Chemical
(1)
View all products
-
Phosphatase Inducers
(2)
View all products
-
Phosphatase Degraders
(7)
View all products
-
Phosphatase Controls
(3)
View all products
-
Phosphatase Substrates
(7)
View all products
-
Phosphatase Ligands
(11)
View all products
-
Phosphatase Proteins
(66)
View all products
-
Phosphatase Related Products (730)
Related Products (730)
-
Recombinant Proteins (66)
-
Antibodies (40)
-
Related Compound Screening Libraries (1)
-
IPA
0 ImagesCat. No.: HY-149590CAS No.: 200348-48-7IPA is a specific Sec18/NSF inhibitor. IPA binds to phosphatidic acid competitively, induces conformational rigidification of Sec18/NSF, disrupts its essential flexibility, and blocks SNARE priming and vacuolar membrane fusion. IPA can be used to investigate the activity of Sec18 and SNARE priming kinetics.
-
Pentamidine (Standard)
0 ImagesPentamidine (Standard) is the analytical standard of Pentamidine. This product is intended for research and analytical applications. Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.
-
G6PC modulator-1
0 ImagesCat. No.: HY-186004CAS No.: 237403-58-6G6PC modulator-1 is a G6PC modulator.
-
MKP5 modulator-1
0 ImagesCat. No.: HY-164931CAS No.: 2460758-05-6MKP5 modulator-1 (Page 14) is a MKP5 modulator with an IC50 of 2.46 μM. MKP5 modulator-1 can be used for the research of fibrotic diseases.
-
Voclosporin (Standard)
0 ImagesSynonyms: ISAtx-247 (Standard)Voclosporin (Standard) is the analytical standard of Voclosporin. This product is intended for research and analytical applications. Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor.
-
pNPPT cyclohexanamine
0 ImagesCat. No.: HY-187648CAS No.: 167698-72-8Synonyms: p-Nitrophenyl phosphorothioate cyclohexanaminepNPPT cyclohexanamine (p-Nitrophenyl phosphorothioate cyclohexanamine) is a dianionic aryl thiophosphate monoester substrate of PP1γ (protein phosphatase 1γ). PP1γ catalyzes the hydrolysis of pNPPT cyclohexanamine.
-
Rbin-1 (Standard)
0 ImagesCat. No.: HY-100816RCAS No.: 328023-11-6Synonyms: Ribozinoindole-1 (Standard)Rbin-1 (Standard) is the analytical standard of Rbin-1 (HY-100816). This product is intended for research and analytical applications. Rbin-1 is a potent, reversible, and specific chemical inhibitor of eukaryotic ribosome biogenesis. Rbin-1 inhibits the ATPase with GI50 of 136 nM. Rbin-1 is a potent and selective chemical inhibitor of Midasin (Mdn1).
-
YZ9 (Standard)
0 ImagesCat. No.: HY-110156RCAS No.: 6093-71-6YZ9 (Standard) is the analytical standard of YZ9 (HY-110156). This product is intended for research and analytical applications. Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki value of 0.094 µM. Y29 exhibits antitumor effects against cervical cancer.
-
SHP099 (Standard)
0 ImagesCat. No.: HY-100388RCAS No.: 1801747-42-1SHP099 (Standard) is the analytical standard of SHP099. This product is intended for research and analytical applications. SHP099 is an allosteric SHP2 inhibitor, with IC50s of 0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2, SHP2D61Y, SHP2E69K, SHP2A72V, SHP2E76K. SHP099 inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC50: 0.32 and 1.73 μM). SHP099 inhibits RAS-ERK signaling and inhibits tumor growth.
-
Alloisoimperatorin
0 ImagesCat. No.: HY-N8366CAS No.: 35214-83-6Alloisoimperatorin (Compound 5) is a phytoestrogen that can be isolated from Angelica dahurica. Alloisoimperatorin can induce alkaline phosphatase (AP) activity with an EC50 of 0.8 μg/mL. Alloisoimperatorin can be used in the study of hormone-dependent cancers and the alleviation of menopausal symptoms.
-
bpV(bipy) hydrate
0 ImagesCat. No.: HY-131549ACAS No.: 1173697-60-3bpV(bipy) hydrate is the inhibitor for phosphoinositide 3-phosphatase (PTEN) and protein tyrosine phosphatases (PTP-β and PTP-1B) with IC50s of 18, 60.3, and 164 nM, respectively.
-
(E/Z)-3PO
0 Images(E/Z)-3PO is a potent PFKFB3 inhibitor. (E/Z)-3PO can inhibit the glycolysis process, reduce the extracellular acidification rate, and inhibit the capillary tube formation, migration of endothelial cells, and the formation of aortic sprouts, thereby suppressing angiogenesis. (E/Z)-3PO is promising for research of diseases such as cancer, acute lung injury, pulmonary fibrosis, and atherosclerosis.
-
L-Ascorbic acid 2-phosphate trisodium (Standard)
0 ImagesSynonyms: 2-Phospho-L-ascorbic acid trisodium (Standard)L-Ascorbic acid 2-phosphate (trisodium) (Standard) is the analytical standard of L-Ascorbic acid 2-phosphate (trisodium). This product is intended for research and analytical applications. L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3].
-
PP48
0 ImagesCat. No.: HY-180517CAS No.: 2629270-03-5PP48 is a compound that interacts with MOB4, with a pTE50 value of 5.4. PP48 interacts with MOB4 (Cys134).
-
Austocystins I
0 ImagesCat. No.: HY-N20727CAS No.: 58775-51-2Austocystins I is a toxin and protein tyrosine phosphatase inhibitor, with an IC50 of 16 μM against MEG2 and an IC50 of 19 μM against CDC25B. Austocystins I exhibits lethal toxicity to brine shrimp. Austocystins I can be used in the research of cancer and type 2 diabetes.
-
Stibophen
0 ImagesCat. No.: HY-180388CAS No.: 15489-16-4Stibophen is a potent antiparasitic agent is effective against Litomosoides carinii, Dipetalonema witei, and Brugia pahangi. Stibophen inhibits lactate accumulation and phosphofructokinases (PFK) activity in adult filariids. Stibophen also inhibits Ascaris and Hymenolepis diminuta PFK without inhibiting mammalian liver PFK. Stibophen can be used for the research of schistosomiasis and filariid infections.
-
EBOV-IN-11
0 ImagesCat. No.: HY-125258CAS No.: 752216-12-9EBOV-IN-11 is a protein phosphatase 1 (PP1) inhibitor, with Kd values of 1.88 nM and 8.01 nM against wild-type and quadruple-mutant PP1, respectively. EBOV-IN-11 potently inhibits the replication and transcription of EBOV-eGFP virus. EBOV-IN-11 can be used in studies related to Ebola virus infection.
-
Calcium glucoheptonate
0 ImagesCat. No.: HY-W404758CAS No.: 23351-51-1Calcium glucoheptonate is a highly water-soluble calcium supplement. Calcium glucoheptonate can increase the proliferation rate and Calcium intake of MG-63 cells and increase the activity of alkaline phosphatase (ALP). Calcium glucoheptonate can upregulate the expression of osteogenic-related genes and proteins,such as collagen-1, osteocalcin and osteocalcin. Calcium glucoheptonate can be used for the researches of osteoporosis and hypocalcemia.
-
Pentamidine dihydrochloride
0 ImagesCat. No.: HY-B0537ACAS No.: 50357-45-4Synonyms: MP-601205 dihydrochloridePentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.
-
Methyl syringate (Standard)
0 ImagesMethyl syringate is a selective TRPA1 agonist. Methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway. Methyl syringate is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate is a chemical marker of Asphodel monofloral honey. Methyl syringate contributes to the antibacterial activity of honey. Methyl syringate inhibits aflatoxin production. Methyl syringate can contribute to weight suppression. Methyl syringate can be studies for cancer prevention (e.g. lung cancer), suppression of hypoxia-induced inflammatory response and tumorigenesis.
