pNPPT cyclohexanamine
pNPPT cyclohexanamine (p-Nitrophenyl phosphorothioate cyclohexanamine) is a dianionic aryl thiophosphate monoester substrate of PP1γ (protein phosphatase 1γ). PP1γ catalyzes the hydrolysis of pNPPT cyclohexanamine.
For research use only. We do not sell to patients.
- CAS No.: 167698-72-8
- Formula: C18H32N3O5PS
- Molecular Weight:433.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
pNPPT (compound 2a) cyclohexanamine is efficiently hydrolyzed by wild-type PP1γ, with a maximum catalytic efficiency of 31 M-1s-1 and a second-order rate acceleration ratio of 1.7 × 1011. The transition state is characterized by restricted leaving group bond cleavage and effective general acid neutralization of the leaving group. The hydrolysis catalytic efficiency decreases for the PP1 R96K and PP1 R221K single mutants of PP1γ, with corresponding catalytic efficiency values of 0.8 M-1s-1 and 1.9 M-1s-1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 167698-72-8
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Molecular Weight 433.50
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Formula C18H32N3O5PS
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SMILES
O=P(O)(S)OC(C=C1)=CC=C1[N+]([O-])=O.NC2CCCCC2.NC3CCCCC3
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Synonyms
p-Nitrophenyl phosphorothioate cyclohexanamine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
pNPPT cyclohexanamine Related Classifications
HY-187648 Related Classifications
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