Phosphatase Ligand

OncoACP3 TFA is a small-molecule ligand of prostatic acid phosphatase (ACP3) with an IC₅₀ of 0.30 nM. OncoACP3 TFA has a modular structure that supports flexible payload delivery. After radiolabeling with Lu-177 it selectively accumulates in ACP3-expressing tumors with a long retention time, enabling targeted radiation delivery. OncoACP3 TFA is applicable to research related to prostate cancer.

ACP3 ligand 1 is a ligand of Acid Phosphatase 3 (ACP3, ACPP). ACP3 ligand 1 interacts with ACP3 expressed on the surface of tumor cells for in vivo pharmaco-delivery applications.

CRT0063465 is a Ligand of HumanPGK1andStress Sensor DJ1, with theK_dof 24 μM ofPGK1. CRT0063465 modulates the shelterin complex composition and telomere Length.

PTPN2 ligand 2 is a PTPN2 ligand and can be used for the synthesis of PROTACs, such as PROTAC PTPN2 degrader-2 (HY-153938).

PTPN2 ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTAC). PTPN2 ligand 1 can be used to synthesize PVD-06 (HY-149760).

SHIP1-IN-1 is an orally active, blood-brain barrier-permeable SHIP1 ligand. SHIP1-IN-1 exhibits IC₅₀ values of 384 μM and 177 μM against human SHIP1, and an IC₅₀ value of 379 μM against murine SHIP1. SHIP1-IN-1 alters the binding state of SHIP1 to phosphatidylinositol membranes, and regulates phosphoinositide pools and phosphorylated AKT levels. SHIP1-IN-1 enhances the uptake of myelin/membrane fragments and amyloid proteins by microglia, alters gene expression and reduces IL-1β levels. SHIP1-IN-1 can be used in studies related to Alzheimer's disease.

ETC-616 is a PROTAC target protein ligand. ETC-616 can be used to synthesize PROTAC EC21 (HY-184678).

12-NBD Stearate is a fluorescent fatty acid analogue. 12-NBD Stearate binds to fatty acid binding protein (FABP) and sterol carrier protein-2 (SCP-2). Overexpressing sterol carrier protein-2 (SCP-2) 15-kDa isoform enhances 12-NBD Stearate transport. 12-NBD Stearate is a tool for microscopic long chain fatty acids (LCFA) uptake and internalization studies.

PTPN2 ligand-Linker Conjugate 1 is a conjugate of the PTPN2 target protein ligand and linker, which can be used for the synthesis of PROTACs, such as PROTAC PTPN2 degrader-2 (HY-153938).

OncoACP3 is a small-molecule ligand of prostatic acid phosphatase (ACP3) with an IC₅₀ of 0.30 nM. OncoACP3 has a modular structure that supports flexible payload delivery. After radiolabeling with Lu-177 it selectively accumulates in ACP3-expressing tumors with a long retention time, enabling targeted radiation delivery. OncoACP3 is applicable to research related to prostate cancer.