3027375-00-1
Chemical Structure
SHIP1-IN-1
- CAS No.: 3027375-00-1
- Formula:C20H21ClN4O
- Molecular Weight:368.86
InChIKey: OKACDRBQWQNLCC-UHFFFAOYSA-N
SMILES: ClC(C=CC=C1)=C1COC2=CN=CC(C3=CN(C4CCNCC4)N=C3)=C2
Biological Activity: SHIP1-IN-1 is an orally active, blood-brain barrier-permeable SHIP1 ligand. SHIP1-IN-1 exhibits IC50 values of 384 μM and 177 μM against human SHIP1, and an IC50 value of 379 μM against murine SHIP1. SHIP1-IN-1 alters the binding state of SHIP1 to phosphatidylinositol membranes, and regulates phosphoinositide pools and phosphorylated AKT levels. SHIP1-IN-1 enhances the uptake of myelin/membrane fragments and amyloid proteins by microglia, alters gene expression and reduces IL-1β levels. SHIP1-IN-1 can be used in studies related to Alzheimer's disease[1][2].
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SHIP1-IN-1 | SHIP1-IN-1 is an orally active, blood-brain barrier-permeable SHIP1 ligand. SHIP1-IN-1 exhibits IC50 values of 384 μM and 177 μM against human SHIP1, and an IC50 value of 379 μM against murine SHIP1. SHIP1-IN-1 alters the binding state of SHIP1 to phosphatidylinositol membranes, and regulates phosphoinositide pools and phosphorylated AKT levels. SHIP1-IN-1 enhances the uptake of myelin/membrane fragments and amyloid proteins by microglia, alters gene expression and reduces IL-1β levels. SHIP1-IN-1 can be used in studies related to Alzheimer's disease. | |||||||||||||||||||||
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- [1]. Jesudason CD, et al. Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease Models. bioRxiv [Preprint]. 2026 Jan 2:2025.12.31.697127.
- [2]. Richardson TI, et al. Crizotinib analogues as ship1 inhibitors useful to treat alzheimer's diseases. WO, WO2024015759A1. 2024-01-18.
Keywords
