CRT0063465
Based on 1 Customer Validation
CRT0063465 is a Ligand of HumanPGK1andStress Sensor DJ1, with theKdof 24 μM ofPGK1. CRT0063465 modulates the shelterin complex composition and telomere Length.
For research use only. We do not sell to patients.
- Purity: 99.64%
- Formula: C17H16BrN3O2
- Molecular Weight:374.23
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
CRT0063465 (10 nM, 1 week) modulates the composition of shelterin complexes in unstressed HCT116 cells[1].
CRT0063465 (100 nM, up to 100 h) has protective effect against Bleomycin (HY-17565)-induced cytotoxicity in A2780 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 374.23
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Formula C17H16BrN3O2
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Color Off-white to light yellow
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SMILES
CC1=C(CCC(O)=O)C(C)=NC2=CC(C3=CC=C(Br)C=C3)=NN12
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 20 mg/mL (53.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6722 mL | 13.3608 mL | 26.7215 mL | 66.8038 mL |
| 5 mM | 0.5344 mL | 2.6722 mL | 5.3443 mL | 13.3608 mL | |
| 10 mM | 0.2672 mL | 1.3361 mL | 2.6722 mL | 6.6804 mL | |
| 15 mM | 0.1781 mL | 0.8907 mL | 1.7814 mL | 4.4536 mL | |
| 20 mM | 0.1336 mL | 0.6680 mL | 1.3361 mL | 3.3402 mL | |
| 25 mM | 0.1069 mL | 0.5344 mL | 1.0689 mL | 2.6722 mL | |
| 30 mM | 0.0891 mL | 0.4454 mL | 0.8907 mL | 2.2268 mL | |
| 40 mM | 0.0668 mL | 0.3340 mL | 0.6680 mL | 1.6701 mL | |
| 50 mM | 0.0534 mL | 0.2672 mL | 0.5344 mL | 1.3361 mL |
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