SHP2 Inhibitor

SHP2 Inhibitors (59):

Cat. No.	Product Name	Effect	Purity

HY-100388

SHP099	Inhibitor	99.80%
SHP099 is a potent, selective, orally available SHP2 inhibitor with an IC₅₀ of 70 nM.

HY-136173

Batoprotafib	Inhibitor	99.43%
Batoprotafib (TNO155) is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC₅₀=0.011 µM). Batoprotafib has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors.

HY-B0183

Ellagic acid	Inhibitor	99.23%
Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive inhibitor of CK2 and SHP2, with an IC₅₀ of 40 nM and a K_i of 20 nM.

HY-116009

RMC-4550	Inhibitor	99.32%
RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC₅₀ of 0.583 nM.

HY-141523

Vociprotafib	Inhibitor	99.19%
Vociprotafib (RMC-4630) is a SHP2 inhibitor, a phosphatase whose inhibition blocks activation of the RAS-RAF-MEK-ERK signaling pathway. Vociprotafib has antitumor activity.

HY-157318

PB17-026-01	Inhibitor
PB17-026-01 is a potent SHP2 allosteric inhibitor and shows the highest inhibitory activity with an IC₅₀ value of 38.9?nM. PB17-026-01 can be used for the research of tumor.

HY-149607

SHP2-IN-22	Inhibitor
SHP2-IN-22 is SHP2 allosteric inhibitor with an IC₅₀ value of 17.7 nM. SHP2-IN-22 inhibits the proliferation, migration, and invasion of MIA PaCa-2 pancreatic cancer cells. SHP2-IN-22 can be used for Kirsten rat sarcoma viral oncogene (KRAS) mutant cancer research.

HY-100388A

SHP099 monohydrochloride	Inhibitor	99.92%
SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC₅₀ of 70 nM.

HY-18756

NSC-87877	Inhibitor	≥99.0%
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26).

HY-112368

PHPS1	Inhibitor	99.97%
PHPS1 is a potent and selective Shp2 inhibitor with K_is of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively.

HY-100595

Sodium stibogluconate	Inhibitor	98.27%
Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase. Sodium stibogluconate inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL, respectively.

HY-137092

IACS-13909	Inhibitor	99.97%
IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC₅₀ of 15.7 nM and a K_d of 32 nM. IACS-13909 is more selective for SHP2 than other phosphatases (including SHP1). IACS-13909 has antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinases (RTK)-dependent cancers.

HY-134885

RMC-0331	Inhibitor	98.96%
RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction.

HY-144903

Migoprotafib	Inhibitor	98.06%
Migoprotafib (GDC-1971) (compound 199) is a SHP2 inhibitor.

HY-101964

SPI-112	Inhibitor
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC₅₀s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively.

HY-108944

LYP-IN-1	Inhibitor	99.78%
LYP-IN-1 is a potent, selective and specific LYP inhibitor with a K_i and an IC₅₀ of 110 nM and 0.259 μM, respectively. LYP-IN-1 also has selectivity for a large panel of PTPs, such as SHP1 (IC₅₀=5 μM) and SHP2 (IC₅₀=2.5 μM). LYP-IN-1 exhibits highly efficacious cellular activity in T- and mast cells. LYP-IN-1 can be used for the study of autoimmune disorders. LYP-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-153740

PF-07284892	Inhibitor	99.63%
PF-07284892 (ARRY-558) is a potent and orally active SHP2 inhibitor with an IC₅₀ value of 21 nM. PF-07284892 decreases the expression of pERK.

HY-131132A

JAB-3068 hydrochloride	Inhibitor	98.74%
JAB-3068 (SHP2-IN-6) hydrochloride is a potent SHP2 inhibitor with an IC₅₀ of 25.8 nM. JAB-3068 hydrochloride is extracted from patent WO2017211303A1, compound 7.

HY-115925

SHP2-IN-9	Inhibitor	98.68%
SHP2-IN-9 is a specific SHP2 inhibitor (IC₅₀ =1.174 μM) with enhanced blood–brain barrier penetration. SHP2-IN-9 shows 85-fold more selective for SHP2 than SHP1. SHP2-IN-9 inhibits SHP2-mediated cell signal transduction and cancer cell proliferation, and inhibits the growth of cervix cancer tumors and glioblastoma growth in vivo.

HY-114397

SHP394	Inhibitor	99.41%
SHP394 is an orally active, selective and allosteric inhibitor of SHP2, with an IC₅₀ of 23 nM.

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