NSC-13030
NSC-13030 is a SHP2 inhibitor with an IC50 value of 3.2 μM. NSC-13030 reduces the proliferation and viability of breast cancer cells. NSC-13030 is applicable to breast cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 5442-51-3
- Formula: C18H14ClNO5S
- Molecular Weight:391.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
NSC-13030 (100 μM; 5 min pre-incubation, 90 min substrate incubation) potently and selectively inhibits purified SHP2 protein with an IC50 of 3.2 μM, and shows weak inhibition of purified SHP1 protein with an IC50 of 85.4 μM[1].
NSC-13030 (0.16-20 μM; 48 h) dose-dependently reduces the proliferation and viability of MCF-7 breast cancer cells, with a 42.1% reduction in proliferation and 64.4% reduction in viability at 20 μM after 48 h of incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 estrogen-positive breast cancer cells
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Concentration:0.16, 0.8, 4, and 20 μM
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Incubation Time:48 h
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Result:Reduced MCF-7 cell proliferation and viability in a dose-dependent manner.
Reduced MCF-7 cell proliferation by 42.1% at 20 μM compared to DMSO vehicle control.
Reduced MCF-7 cell viability by 64.4% at 20 μM compared to DMSO vehicle control.
Chemical Information
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CAS No. 5442-51-3
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Molecular Weight 391.83
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Formula C18H14ClNO5S
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SMILES
O=C(CC(C(O)=O)SC1=C2C=CC(Cl)=CC2=NC3=C1C=C(OC)C=C3)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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