2. Protein Tyrosine Kinase/RTK
  3. SHP2
  4. NSC-13030

NSC-13030 is a SHP2 inhibitor with an IC50 value of 3.2 μM. NSC-13030 reduces the proliferation and viability of breast cancer cells. NSC-13030 is applicable to breast cancer-related research.

For research use only. We do not sell to patients.

NSC-13030

NSC-13030 Chemical Structure

CAS No. : 5442-51-3

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Description

NSC-13030 is a SHP2 inhibitor with an IC50 value of 3.2 μM. NSC-13030 reduces the proliferation and viability of breast cancer cells. NSC-13030 is applicable to breast cancer-related research[1].

In Vitro

NSC-13030 (100 μM; 5 min pre-incubation, 90 min substrate incubation) potently and selectively inhibits purified SHP2 protein with an IC50 of 3.2 μM, and shows weak inhibition of purified SHP1 protein with an IC50 of 85.4 μM[1].
NSC-13030 (0.16-20 μM; 48 h) dose-dependently reduces the proliferation and viability of MCF-7 breast cancer cells, with a 42.1% reduction in proliferation and 64.4% reduction in viability at 20 μM after 48 h of incubation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC-13030 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF-7 estrogen-positive breast cancer cells
Concentration: 0.16, 0.8, 4, and 20 μM
Incubation Time: 48 h
Result: Reduced MCF-7 cell proliferation and viability in a dose-dependent manner.
Reduced MCF-7 cell proliferation by 42.1% at 20 μM compared to DMSO vehicle control.
Reduced MCF-7 cell viability by 64.4% at 20 μM compared to DMSO vehicle control.
Molecular Weight

391.83

Formula

C18H14ClNO5S
CAS No.
SMILES

O=C(CC(C(O)=O)SC1=C2C=CC(Cl)=CC2=NC3=C1C=C(OC)C=C3)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NSC-13030 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC-130305442-51-3NSC13030NSC 13030SHP2Src homology phosphatase 2PTPN11SHP1MCF-7 cellsdouble-stranded DNAbreast cancerInhibitorinhibitorinhibit

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