2. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK
  3. Phosphatase SHP2
  4. PTP Inhibitor IV

PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an 50 of 5.21 μM. PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with 50s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively.

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PTP Inhibitor IV Chemical Structure

PTP Inhibitor IV Chemical Structure

CAS No. : 329317-98-8

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Based on 1 publication(s) in Google Scholar

PTP Inhibitor IV Related Antibodies

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Description

PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an 50 of 5.21 μM[1]. PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with 50s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively[2].

IC50 & Target

IC50: 1.8 μM (SHP-2), 2.5 μM (PTP1B), 8.4 μM (PTP-ε), 13 μM (PTP Meg-2), 20 μM (PTP-σ), 6.4 μM (PTP-β), and 6.7 μM (PTP-μ)[2]; 5.21 μM (DUSP14)[1]
In Vitro

PTP Inhibitor IV down-regulates the catalytic activity of DUSP14 by binding in the catalytic site[1].
PTP Inhibitor IV (0-100 μM; 3 hours) effectively and specifically inhibits DUSP14-mediated dephosphorylation of JNK[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PTP Inhibitor IV Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK 293 cells
Concentration: 0, 10 μM, 50 μM, or 100 μM
Incubation Time: 3 hours
Result: Effectively penetrated the cells and inhibited DUSP14 activity.
Molecular Weight

608.62

Formula

C26H26F6N2O4S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C1=CC=C(C(C)(C2=CC=C(NS(C(F)(F)F)(=O)=O)C=C2)C)C=C1)(C3=CC=C(NS(C(F)(F)F)(=O)=O)C=C3)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (410.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6431 mL 8.2153 mL 16.4306 mL
5 mM 0.3286 mL 1.6431 mL 3.2861 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6431 mL 8.2153 mL 16.4306 mL 41.0765 mL
5 mM 0.3286 mL 1.6431 mL 3.2861 mL 8.2153 mL
10 mM 0.1643 mL 0.8215 mL 1.6431 mL 4.1077 mL
15 mM 0.1095 mL 0.5477 mL 1.0954 mL 2.7384 mL
20 mM 0.0822 mL 0.4108 mL 0.8215 mL 2.0538 mL
25 mM 0.0657 mL 0.3286 mL 0.6572 mL 1.6431 mL
30 mM 0.0548 mL 0.2738 mL 0.5477 mL 1.3692 mL
40 mM 0.0411 mL 0.2054 mL 0.4108 mL 1.0269 mL
50 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.8215 mL
60 mM 0.0274 mL 0.1369 mL 0.2738 mL 0.6846 mL
80 mM 0.0205 mL 0.1027 mL 0.2054 mL 0.5135 mL
100 mM 0.0164 mL 0.0822 mL 0.1643 mL 0.4108 mL
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PTP Inhibitor IV Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTP Inhibitor IV329317-98-8PhosphataseSHP2Src homology phosphatase 2PTPN11SHP-2PTP1BPTP-εPTP Meg-2PTP-σPTP-βPTP-μDUSP14Inhibitorinhibitorinhibit

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