PTP Inhibitor IV
Based on 1 publication(s) in Google Scholar
PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an 50 of 5.21 μM. PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with 50s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.86%
- CAS No.: 329317-98-8
- 화학식: C26H26F6N2O4S2
- 분자량:608.62
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) PTP Inhibitor IV
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Biological Activity
제품 설명
IC50 & Target
IC50: 1.8 μM (SHP-2), 2.5 μM (PTP1B), 8.4 μM (PTP-ε), 13 μM (PTP Meg-2), 20 μM (PTP-σ), 6.4 μM (PTP-β), and 6.7 μM (PTP-μ)[2]; 5.21 μM (DUSP14)[1]
In Vitro
PTP Inhibitor IV down-regulates the catalytic activity of DUSP14 by binding in the catalytic site[1].
PTP Inhibitor IV (0-100 μM; 3 hours) effectively and specifically inhibits DUSP14-mediated dephosphorylation of JNK[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:HEK 293 cells
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Concentration:0, 10 μM, 50 μM, or 100 μM
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Incubation Time:3 hours
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Result:Effectively penetrated the cells and inhibited DUSP14 activity.
Chemical Information
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CAS No. 329317-98-8
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Appearance Solid
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분자량 608.62
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화학식 C26H26F6N2O4S2
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Color White to off-white
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SMILES
CC(C1=CC=C(C(C)(C2=CC=C(NS(C(F)(F)F)(=O)=O)C=C2)C)C=C1)(C3=CC=C(NS(C(F)(F)F)(=O)=O)C=C3)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
용액&용해도
In Vitro:
DMSO : 250 mg/mL (410.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Jae Eun Park, et al. PTP inhibitor IV protects JNK kinase activity by inhibiting dual-specificity phosphatase 14 (DUSP14). Biochem Biophys Res Commun. 2009 Oct 2;387(4):795-9. [Content Brief]
[2]. Ping Huang, et al. Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. Bioorg Med Chem. 2003 Apr 17;11(8):1835-49. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6431 mL | 8.2153 mL | 16.4306 mL | 41.0765 mL |
| 5 mM | 0.3286 mL | 1.6431 mL | 3.2861 mL | 8.2153 mL | |
| 10 mM | 0.1643 mL | 0.8215 mL | 1.6431 mL | 4.1077 mL | |
| 15 mM | 0.1095 mL | 0.5477 mL | 1.0954 mL | 2.7384 mL | |
| 20 mM | 0.0822 mL | 0.4108 mL | 0.8215 mL | 2.0538 mL | |
| 25 mM | 0.0657 mL | 0.3286 mL | 0.6572 mL | 1.6431 mL | |
| 30 mM | 0.0548 mL | 0.2738 mL | 0.5477 mL | 1.3692 mL | |
| 40 mM | 0.0411 mL | 0.2054 mL | 0.4108 mL | 1.0269 mL | |
| 50 mM | 0.0329 mL | 0.1643 mL | 0.3286 mL | 0.8215 mL | |
| 60 mM | 0.0274 mL | 0.1369 mL | 0.2738 mL | 0.6846 mL | |
| 80 mM | 0.0205 mL | 0.1027 mL | 0.2054 mL | 0.5135 mL | |
| 100 mM | 0.0164 mL | 0.0822 mL | 0.1643 mL | 0.4108 mL |
PTP Inhibitor IV Related Classifications
HY-112478 Related Classifications
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