329317-98-8
Chemical Structure
PTP Inhibitor IV
- CAS No.: 329317-98-8
- Formula:C26H26F6N2O4S2
- Molecular Weight:608.62
IUPAC Name: N,N'-((1,4-phenylenebis(propane-2,2-diyl))bis(4,1-phenylene))bis(1,1,1-trifluoromethanesulfonamide)
InChIKey: JWNAVYMNAQDLHX-UHFFFAOYSA-N
SMILES: CC(C1=CC=C(C(C)(C2=CC=C(NS(C(F)(F)F)(=O)=O)C=C2)C)C=C1)(C3=CC=C(NS(C(F)(F)F)(=O)=O)C=C3)C
Biological Activity: PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an 50 of 5.21 μM[1]. PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with 50s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PTP Inhibitor IV | 99.86% | PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an 50 of 5.21 μM. PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with 50s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively. | ||||||||||||||||||||
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References
- [1]. Jae Eun Park, et al. PTP inhibitor IV protects JNK kinase activity by inhibiting dual-specificity phosphatase 14 (DUSP14). Biochem Biophys Res Commun. 2009 Oct 2;387(4):795-9. [Content Brief]
- [2]. Ping Huang, et al. Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. Bioorg Med Chem. 2003 Apr 17;11(8):1835-49. [Content Brief]
