2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. GI-530159

GI-530159 is a selective opener of TREK1 and TREK2 potassium channels. GI-530159 displays selectivity for TREK1/2 over TRAAK, TASK3 and other potassium channels, with an EC50 of 0.76 μM for TREK1. GI-530159 reduces rat dorsal root ganglion neuron excitability and shows potential analgesic effect.

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GI-530159 Chemical Structure

GI-530159 Chemical Structure

CAS No. : 69563-88-8

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Based on 1 publication(s) in Google Scholar

GI-530159 Related Antibodies

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Description

GI-530159 is a selective opener of TREK1 and TREK2 potassium channels. GI-530159 displays selectivity for TREK1/2 over TRAAK, TASK3 and other potassium channels, with an EC50 of 0.76 μM for TREK1. GI-530159 reduces rat dorsal root ganglion neuron excitability and shows potential analgesic effect[1].

IC50 & Target

Target: TREK1/2[1]
In Vitro

TREK (TWIK-related K) two pore domain potassium (K2P) channels regulate the excitability of somatosensory nociceptive neurons and mediate pain perception[1].
GI-530159 (1 µM or 10 µM) shows selectivity and activates TREK1 and TREK2 channels but shows no significant effects on TRAAK channels or K channels tested[1].
GI-530159 (0.1-30 µM) activates recombinant human TREK1 channels with EC50s of 0.8 µM and 0.9 µM from Rb efflux and electrophysiological experiments, respectively[1].
GI-530159 (1 µM) reduces rat dorsal root ganglion (DRG) neuron excitability, results in firing frequency reduction and a small hyperpolarisation of resting membrane potential (RMP)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GI-530159 Related Antibodies
Molecular Weight

518.45

Formula

C27H20F6N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(C(C1=CC=C(OC2=CC=C(N)C=C2)C=C1)(C3=CC=C(OC4=CC=C(N)C=C4)C=C3)C(F)(F)F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (482.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9288 mL 9.6441 mL 19.2883 mL
5 mM 0.3858 mL 1.9288 mL 3.8577 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9288 mL 9.6441 mL 19.2883 mL 48.2207 mL
5 mM 0.3858 mL 1.9288 mL 3.8577 mL 9.6441 mL
10 mM 0.1929 mL 0.9644 mL 1.9288 mL 4.8221 mL
15 mM 0.1286 mL 0.6429 mL 1.2859 mL 3.2147 mL
20 mM 0.0964 mL 0.4822 mL 0.9644 mL 2.4110 mL
25 mM 0.0772 mL 0.3858 mL 0.7715 mL 1.9288 mL
30 mM 0.0643 mL 0.3215 mL 0.6429 mL 1.6074 mL
40 mM 0.0482 mL 0.2411 mL 0.4822 mL 1.2055 mL
50 mM 0.0386 mL 0.1929 mL 0.3858 mL 0.9644 mL
60 mM 0.0321 mL 0.1607 mL 0.3215 mL 0.8037 mL
80 mM 0.0241 mL 0.1206 mL 0.2411 mL 0.6028 mL
100 mM 0.0193 mL 0.0964 mL 0.1929 mL 0.4822 mL
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GI-530159 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GI-53015969563-88-8GI530159GI 530159Potassium ChannelKcsAneuronexcitabilityDRGdorsal root gangliafiring frequencyanalgesictwo pore domain potassium channelsselectiveHEK293CHOtsA-201Rb effluxelectrophysiologicalresting membrane potentialRMPInhibitorinhibitorinhibit

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