2. Immunology/Inflammation Protein Tyrosine Kinase/RTK NF-κB
  3. Human leukocyte immunoglobulin (Ig)-like receptors (LILR) SHP1 SHP2 NF-κB
  4. IB15C

IB15C is an ILT3 (LILRB4) inhibitor with a human Kd of 0.92 μM. IB15C binds to a specific ILT3 pocket, disrupts ApoE interaction, and interferes with downstream inhibitory signaling pathways. IB15C reduces SHP1 and SHP2 phosphorylation, suppresses pro-inflammatory cytokine secretion, enhances amyloid uptake, and attenuates NF-κB activation. IB15C can be used for the research of alzheimer's disease.

For research use only. We do not sell to patients.

IB15C

IB15C Chemical Structure

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IB15C Related Antibodies

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LILRB

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description

IB15C is an ILT3 (LILRB4) inhibitor with a human Kd of 0.92 μM. IB15C binds to a specific ILT3 pocket, disrupts ApoE interaction, and interferes with downstream inhibitory signaling pathways. IB15C reduces SHP1 and SHP2 phosphorylation, suppresses pro-inflammatory cytokine secretion, enhances amyloid uptake, and attenuates NF-κB activation. IB15C can be used for the research of alzheimer's disease[1].

IC50 & Target[1]

LILRB

0.92 μM (Kd)

In Vitro

IB15C binds to recombinant human ILT3 extracellular domain with submicromolar affinity, showing an apparent Kd of 0.92 μM[1].
IB15C inhibits the interaction between recombinant human ILT3 extracellular domain and ApoE in an ELISA-based assay with an IC50 of 0.48 μM[1].
IB15C inhibits the interaction between recombinant human ILT3 extracellular domain and ApoE in a BLI-based real-time assay with an IC50 of 0.64 μM[1].
IB15C (1-10 μM) reverses ILT3-dependent inhibitory signaling, reduces inflammatory activation, and restores Aβ uptake in human iPSC-derived microglia under Aβ42- and ApoE-driven conditions, with no detectable cytotoxicity at concentrations up to 10 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IB15C Related Antibodies
Molecular Weight

383.44

Formula

C21H25N3O4
SMILES

COC1=C(OC)C=CC(C(C)CNC(C2=CC(C(C(C)C)=NO3)=C3N=C2)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IB15C Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IB15CHuman leukocyte immunoglobulin (Ig)-like receptors (LILR)SHP1SHP2NF-κBHuman leukocyte immunoglobulin (Ig)-like receptorsLILRImmunoglobulin-like transcriptILTLIRMIRCD85Shp1PTPN6Src homology region 2 (SH-2) domain-containing phosphatase 1Src homology phosphatase 2PTPN11Nuclear factor-κBNuclear factor-kappaBILT3alzheimer's diseaseAβ42human iPSC-derived microgliaApoECYP isoformLILRB4Inhibitorinhibitorinhibit

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