1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. NSC-87877

NSC-87877 

Cat. No.: HY-18756 Purity: >99.0%
Handling Instructions

NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26).

For research use only. We do not sell to patients.

NSC-87877 Chemical Structure

NSC-87877 Chemical Structure

CAS No. : 56990-57-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 600 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].

IC50 & Target

IC50: 0.318 μM (shp2), 0.355 μM (shp1)[1].

Molecular Weight

459.45

Formula

C₁₉H₁₃N₃O₇S₂

CAS No.

56990-57-9

SMILES

O=S(C1=C2C=CC=NC2=C(O)C(/N=N/C3=CC=C4C=C(S(=O)(O)=O)C=CC4=C3)=C1)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (10.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1765 mL 10.8826 mL 21.7652 mL
5 mM 0.4353 mL 2.1765 mL 4.3530 mL
10 mM 0.2177 mL 1.0883 mL 2.1765 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

NSC-87877NSC87877NSC 87877PhosphataseInhibitorinhibitorinhibit

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Product name:
NSC-87877
Cat. No.:
HY-18756
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