NSC-87877 disodium 

NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively^[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)^[2].

IC50: 0.318 μM (shp2), 0.355 μM (shp1)^[1].

NSC-87877 (0-0.5 μM, 5 days) inhibits DUSP26 function in NB cell lines^[3].
NSC-87877 (0-0.5 μM, 5 days) results in increased p53 phosphorylation (Ser37 and Ser46) and activation^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NSC-87877 (30 mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

503.42

C₁₉H₁₁N₃Na₂O₇S₂

56932-43-5

O=S(C1=C2C=CC=NC2=C(O)C(/N=N/C3=CC=C4C=C(S(=O)(O[Na])=O)C=CC4=C3)=C1)(O[Na])=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70.  [Content Brief]

  [2]. Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5.  [Content Brief]

  [3]. Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841.  [Content Brief]