NSC-87877 disodium
Based on 3 publication(s) in Google Scholar
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26).
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 56932-43-5
- Formula: C19H11N3Na2O7S2
- Molecular Weight:503.42
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) NSC-87877 disodium
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RT-PCR
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IF
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Histological Imaging/Staining
Biological Activity
IC50: 0.318 μM (shp2), 0.355 μM (shp1)[1].
NSC-87877 (0-0.5 μM, 5 days) inhibits DUSP26 function in NB cell lines[3].
NSC-87877 (0-0.5 μM, 5 days) results in increased p53 phosphorylation (Ser37 and Ser46) and activation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:p53 wild-type neuroblastoma (NB) cell lines.
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Concentration:0, 0.25, 0.5 μM.
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Incubation Time:5 days.
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Result:Resulted in increased p53 phosphorylation (Ser37 and Ser46) and activation, increased activation of downstream p38 effector proteins (heat shock protein 27 (HSP27) and MAP kinase-activated protein kinase 2 (MAPKAPK2)) and poly ADP ribose polymerase/caspase-3 cleavage.
Inhibited DUSP26 function in NB cell lines.
Resulted in apoptosis in many cell lines at varying IC50 levels of 1.84 μM (IMR32), 6.35 μM (SK-N-SH), 8.69 μM (NB-19), 12.6 μM (SMS-KCN), 15.7 μM (SH-SY5Y), 15.8 μM (JF) and 19.0 μM (CHLA-225), respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice[3].
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Dosage:30 mg/kg.
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Administration:IP once daily for 15 days.
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Result:Significantly inhibited NB tumor growth.
Chemical Information
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CAS No. 56932-43-5
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Appearance Solid
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Molecular Weight 503.42
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Formula C19H11N3Na2O7S2
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Color Brown to black
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SMILES
O=S(C1=C2C=CC=NC2=C(O)C(/N=N/C3=CC=C4C=C(S(=O)(O[Na])=O)C=CC4=C3)=C1)(O[Na])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Immunity
B cell-derived acetylcholine promotes liver regeneration by regulating Kupffer cell and hepatic CD8+ T cell function. [Abstract]2025 Apr 23:S1074-7613(25)00165-7. PMID: 40286791 -
Sci Transl Med
Hematopoietic loss of Y chromosome activates immune checkpoints and contributes to impaired senescent cell clearance and renal disease. [Abstract]2025 Aug 6;17(810):eadv4071. PMID: 40768598
NSC-87877 disodium purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2025 Aug 6;17(810):eadv4071. [Abstract]
The percentage of macrophages engulfing senescent cells with or without NSC-87877 (30 mg/kg).
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Neural Regen Res
Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model. [Abstract]2025 Mar 1;20(3):858-872. PMID: 38886958
NSC-87877 disodium purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2025 Mar 1;20(3):858-872. [Abstract]
The mRNA expression levels of SHP2, iNOS, CD86, TNF-α, IL-1β, CD206 and Arg-1 in microglia treated with NSC-87877 and siSHP2 were detected by quantitative polymerase chain reaction (qPCR).
NSC-87877 disodium purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2025 Mar 1;20(3):858-872. [Abstract]
Immunofluorescence staining was used to detect the immunoreactivity of CD163 (green - CoraLite488) and CD86 (red - CoraLite594) in microglia treated with NSC-87877.
NSC-87877 disodium purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2025 Mar 1;20(3):858-872. [Abstract]
The expression of SHP2, iNOS, CD86, CD206, Arg-1 and other proteins in microglia treated with NSC-87877 was detected by Western blotting.
NSC-87877 disodium purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2025 Mar 1;20(3):858-872. [Abstract]
HE staining of mouse spinal cord sections 14 days after SCI. HE staining of transverse and longitudinal sections showed that the lesion area in the SCI+NSC87877 (2 mM) group was significantly smaller than that in the SCI group.
Solvent & Solubility
DMSO : 125 mg/mL (248.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (99.32 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70. [Content Brief]
[2]. Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5. [Content Brief]
[3]. Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.9864 mL | 9.9321 mL | 19.8641 mL | 49.6603 mL |
| 5 mM | 0.3973 mL | 1.9864 mL | 3.9728 mL | 9.9321 mL | |
| 10 mM | 0.1986 mL | 0.9932 mL | 1.9864 mL | 4.9660 mL | |
| 15 mM | 0.1324 mL | 0.6621 mL | 1.3243 mL | 3.3107 mL | |
| 20 mM | 0.0993 mL | 0.4966 mL | 0.9932 mL | 2.4830 mL | |
| 25 mM | 0.0795 mL | 0.3973 mL | 0.7946 mL | 1.9864 mL | |
| 30 mM | 0.0662 mL | 0.3311 mL | 0.6621 mL | 1.6553 mL | |
| 40 mM | 0.0497 mL | 0.2483 mL | 0.4966 mL | 1.2415 mL | |
| 50 mM | 0.0397 mL | 0.1986 mL | 0.3973 mL | 0.9932 mL | |
| 60 mM | 0.0331 mL | 0.1655 mL | 0.3311 mL | 0.8277 mL | |
| 80 mM | 0.0248 mL | 0.1242 mL | 0.2483 mL | 0.6208 mL | |
| DMSO | 100 mM | 0.0199 mL | 0.0993 mL | 0.1986 mL | 0.4966 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
NSC-87877 disodium Related Classifications
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