1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. Bis(maltolato)oxovanadium(IV)

Bis(maltolato)oxovanadium(IV) (Synonyms: BMOV)

Cat. No.: HY-118567
Handling Instructions

Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV) inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectively. Bis(maltolato)oxovanadium(IV) is a potent insulin sensitizer.

For research use only. We do not sell to patients.

Bis(maltolato)oxovanadium(IV) Chemical Structure

Bis(maltolato)oxovanadium(IV) Chemical Structure

CAS No. : 38213-69-3

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Description

Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV) inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectively. Bis(maltolato)oxovanadium(IV) is a potent insulin sensitizer[1][2].

IC50 & Target

IC50: 126 nM (HCPTPA), 109 nM (PTP1B), 26 nM (HPTPβ) and 201 nM (SHP2)[2]

In Vitro

Bis(maltolato)oxovanadium(IV) treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. Bis(maltolato)oxovanadium(IV) (BMOV; 50 μM) treatment also resultes in an increased glucose uptake in C2C12 cells[1].

In Vivo

Bis(maltolato)oxovanadium(IV) (BMOV; 0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; C57BL/6J mice) treatment ameliorates the metabolic phenotype. Liver, skeletal muscle, and adipose tissue revealed a significantly reduced PTP activity in all analysed tissues compared to HFD mice[1].

Animal Model: C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD)[1]
Dosage: 0.75-3.0 mmol
Administration: Intraperitoneal injection; twice weekly; for 6 weeks
Result: Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.
Molecular Weight

317.15

Formula

C₁₂H₁₀O₇V

CAS No.

38213-69-3

SMILES

O=[V+2]([O-]C1=C2C)([O]=C1C=CO2)([O]=C3C=CO4)[O-]C3=C4C

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Bis(maltolato)oxovanadium(IV)BMOVPhosphatasePTPSHP-1type-2diabetesinsulinmetabolicphenotypeglucoseuptakePTP1BHCPTPAHPTPβSHP2Inhibitorinhibitorinhibit

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