Bis(maltolato)oxovanadium(IV)
Based on 1 Customer Validation
Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV) inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectively. Bis(maltolato)oxovanadium(IV) is a potent insulin sensitizer.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 38213-69-3
- Formula: C12H10O7V
- Molecular Weight:317.15
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Kinase Inhibitor Library
HY-L009
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Metabolism/Protease Compound Library
HY-L012
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Protein Tyrosine Kinase Compound Library
HY-L016
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Oxygen Sensing Compound Library
HY-L045
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Orally Active Compound Library
HY-L061
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Phosphatase Inhibitor Library
HY-L081
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Anti-Obesity Compound Library
HY-L087
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Metabolic Enzyme Compound Library
HY-L146
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Multi-Target Compound Library
HY-L176
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MCE Bioactive Compound Library
HY-L001V
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Biological Activity
IC50: 126 nM (HCPTPA), 109 nM (PTP1B), 26 nM (HPTPβ) and 201 nM (SHP2)[2]
Bis(maltolato)oxovanadium(IV) treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. Bis(maltolato)oxovanadium(IV) (BMOV; 50 μM) treatment also resultes in an increased glucose uptake in C2C12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD)[1]
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Dosage:0.75-3.0 mmol
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Administration:Intraperitoneal injection; twice weekly; for 6 weeks
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Result:Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.
Chemical Information
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CAS No. 38213-69-3
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Appearance Solid
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Molecular Weight 317.15
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Formula C12H10O7V
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Color Brown to black
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SMILES
O=[V+2]([O-]C1=C2C)([O]=C1C=CO2)([O]=C3C=CO4)[O-]C3=C4C
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Synonyms
BMOV
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (78.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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Handling Instructions (2659 KB)
References
[1]. Janine Krüger, et al. Inhibition of Src homology 2 domain-containing phosphatase 1 increases insulin sensitivity in high-fat diet-induced insulin-resistant mice. FEBS Open Bio. 2016 Jan 4;6(3):179-89. [Content Brief]
[2]. Kevin G Peters, et al. Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium); unliganded vanadium (VO4) as the active component. J Inorg Biochem. 2003 Aug 1;96(2-3):321-30. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.1531 mL | 15.7654 mL | 31.5308 mL | 78.8271 mL |
| 5 mM | 0.6306 mL | 3.1531 mL | 6.3062 mL | 15.7654 mL | |
| 10 mM | 0.3153 mL | 1.5765 mL | 3.1531 mL | 7.8827 mL | |
| 15 mM | 0.2102 mL | 1.0510 mL | 2.1021 mL | 5.2551 mL | |
| 20 mM | 0.1577 mL | 0.7883 mL | 1.5765 mL | 3.9414 mL | |
| 25 mM | 0.1261 mL | 0.6306 mL | 1.2612 mL | 3.1531 mL | |
| 30 mM | 0.1051 mL | 0.5255 mL | 1.0510 mL | 2.6276 mL | |
| 40 mM | 0.0788 mL | 0.3941 mL | 0.7883 mL | 1.9707 mL | |
| 50 mM | 0.0631 mL | 0.3153 mL | 0.6306 mL | 1.5765 mL | |
| 60 mM | 0.0526 mL | 0.2628 mL | 0.5255 mL | 1.3138 mL |
Bis(maltolato)oxovanadium(IV) Related Classifications
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