1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. RMC-4550

RMC-4550 

Cat. No.: HY-116009 Purity: 99.32%
Handling Instructions

RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM.

For research use only. We do not sell to patients.

RMC-4550 Chemical Structure

RMC-4550 Chemical Structure

CAS No. : 2172651-73-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM.

IC50 & Target

IC50:0.583 nM (SHP2)[1].

In Vitro

RMC-4550 is an allosteric inhibitor of SHP2 and stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. Consistent with an allosteric mode of inhibition, RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but lacks activity against the free catalytic domain of SHP2[1].

Molecular Weight

437.36

Formula

C₂₁H₂₆Cl₂N₄O₂

CAS No.

2172651-73-7

SMILES

ClC1=C(C(C2=NC(CO)=C(N=C2C)N3CCC4(CC3)CO[[email protected]]([[email protected]]4N)C)=CC=C1)Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (285.81 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2864 mL 11.4322 mL 22.8645 mL
5 mM 0.4573 mL 2.2864 mL 4.5729 mL
10 mM 0.2286 mL 1.1432 mL 2.2864 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.76 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.76 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.76 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.32%

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RMC-4550
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HY-116009
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