1. Metabolic Enzyme/Protease
  2. Phosphatase

RMC-4550 

Cat. No.: HY-116009
Handling Instructions

RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM.

For research use only. We do not sell to patients.

RMC-4550 Chemical Structure

RMC-4550 Chemical Structure

CAS No. : 2172651-73-7

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM.

IC50 & Target

IC50:0.583 nM (SHP2)[1].

In Vitro

RMC-4550 is an allosteric inhibitor of SHP2 and stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. Consistent with an allosteric mode of inhibition, RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but lacks activity against the free catalytic domain of SHP2[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2864 mL 11.4322 mL 22.8645 mL
5 mM 0.4573 mL 2.2864 mL 4.5729 mL
10 mM 0.2286 mL 1.1432 mL 2.2864 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

437.36

Formula

C₂₁H₂₆Cl₂N₄O₂

CAS No.

2172651-73-7

SMILES

ClC1=C(C(C2=NC(CO)=C(N=C2C)N3CCC4(CC3)CO[[email protected]]([[email protected]]4N)C)=CC=C1)Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
RMC-4550
Cat. No.:
HY-116009
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RMC-4550

Cat. No.: HY-116009