2498597-94-5
2498597-94-5
Chemical Structure
PF-07284892
Synonym(s): ARRY-558
- CAS No.: 2498597-94-5
- Formula:C21H22ClN7S
- Molecular Weight:439.96
InChIKey: VWHIFLPCODGQHW-HXUWFJFHSA-N
SMILES: N[C@H]1C2(CCN(C3=NN=C(SC4=CC=NC(N)=C4Cl)C=N3)CC2)CC5=CC=CC=C51
Biological Activity: PF-07284892 (ARRY-558) is a potent and orally active SHP2 inhibitor with an IC50 value of 21 nM. PF-07284892 decreases the expression of pERK[1][2].
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PF-07284892 | PF-07284892 (ARRY-558) is a potent and orally active SHP2 inhibitor with an IC50 value of 21 nM. PF-07284892 decreases the expression of pERK. | |||||||||||||||||||||
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References
- [1]. Abdayem P, et al. Ongoing progress in BRAF-mutated non-small cell lung cancer. Clin Adv Hematol Oncol. 2022 Nov;20(11):662-672. [Content Brief]
- [2]. Drilon A, et al. SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy. Cancer Discov. 2023 Jun 3:OF1-OF13. [Content Brief]
Keywords
