15489-16-4
Chemical Structure
Stibophen
- CAS No.: 15489-16-4
- Formula:C12H18Na5O23S4Sb
- Molecular Weight:895.23
SMILES: O=S([O-])(C1=CC2=C(C(S(=O)([O-])=O)=C1)[O-][Sb+3]3([O-]C4=C([O-]3)C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C4)[O-]2)=O.[5 Na+].[7 H2O]
Biological Activity: Stibophen is a potent antiparasitic agent is effective against Litomosoides carinii, Dipetalonema witei, and Brugia pahangi. Stibophen inhibits lactate accumulation and phosphofructokinases (PFK) activity in adult filariids. Stibophen also inhibits Ascaris and Hymenolepis diminuta PFK without inhibiting mammalian liver PFK. Stibophen can be used for the research of schistosomiasis and filariid infections[1][2].
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Stibophen | Stibophen is a potent antiparasitic agent is effective against Litomosoides carinii, Dipetalonema witei, and Brugia pahangi. Stibophen inhibits lactate accumulation and phosphofructokinases (PFK) activity in adult filariids. Stibophen also inhibits Ascaris and Hymenolepis diminuta PFK without inhibiting mammalian liver PFK. Stibophen can be used for the research of schistosomiasis and filariid infections. | |||||||||||||||||||||
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[1]. Stohler, H. R., et al. Chemotherapy of Experimental Schistosomiasis Mansoni: Prophylactic and Protective Activity of Clinically Active Compounds in Mice and Hamsters. Annals of Tropical Medicine & Parasitology, 57(4), 466-480.
- [2]. Saz HJ, et al. The effects of stibophen on phosphofructokinases and aldolases of adult filariids. J Parasitol. 1975;61(5):794-801. [Content Brief]
Keywords
