2. Metabolic Enzyme/Protease Anti-infection
  3. Phosphatase Filovirus
  4. EBOV-IN-11

EBOV-IN-11 is a protein phosphatase 1 (PP1) inhibitor, with Kd values of 1.88 nM and 8.01 nM against wild-type and quadruple-mutant PP1, respectively. EBOV-IN-11 potently inhibits the replication and transcription of EBOV-eGFP virus. EBOV-IN-11 can be used in studies related to Ebola virus infection.

For research use only. We do not sell to patients.

EBOV-IN-11

EBOV-IN-11 Chemical Structure

CAS No. : 752216-12-9

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EBOV-IN-11 Related Antibodies

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Description

EBOV-IN-11 is a protein phosphatase 1 (PP1) inhibitor, with Kd values of 1.88 nM and 8.01 nM against wild-type and quadruple-mutant PP1, respectively. EBOV-IN-11 potently inhibits the replication and transcription of EBOV-eGFP virus. EBOV-IN-11 can be used in studies related to Ebola virus infection[1].

In Vitro

EBOV-IN-11 (Compound C31) (10 μM; 3 d) inhibits the replication of EBOV-eGFP in Vero E6 cells with low initial cytotoxicity[1].
EBOV-IN-11 (100 μM) exhibits <30% cytotoxicity in 293T cells, while it shows no cytotoxicity in PBMCs[1].
EBOV-IN-11 (1-30 μM; 49 h) potently inhibits EBOV replication in Vero E6 cells at concentrations of 3 μM and above, reducing viral titers by 2-3 orders of magnitude[1].
EBOV-IN-11 (10 μM; 48 h) inhibits the transcription of EBOV minigenome in 293T cells, with inhibitory potency comparable to that of 1E7-03[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EBOV-IN-11 Related Antibodies
Molecular Weight

475.50

Formula

C26H25N3O6
CAS No.
SMILES

O=C(OC(C(=O)NC(=O)N)C)C=1C=2C=CC=CC2N=C3C(=CC4=CC=C(OC)C(OC)=C4)CCC31
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EBOV-IN-11 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EBOV-IN-11752216-12-9PhosphataseFilovirusVero E6 cellsperipheral blood mononuclear cellsebola virusProtein Phosphatase 1PBMCsPP1murine serumRVxF site293T cellsVP30Inhibitorinhibitorinhibit

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