2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphatase
  5. Phosphatase Modulator

Phosphatase Modulator

Phosphatase Modulators (3):

Cat. No. Product Name Effect Purity
  • HY-N2217
    Rotundic acid
    		Modulator 99.41%
    Rotundic acid is an orally effective triterpenoid with a Kd value of 51.3 µM for PTP1B. Rotundic acid downregulates the AKT/mTOR pro-survival pathway and modulates the MAPK pathway. Rotundic acid induces cell cycle S-phase arrest, DNA damage and apoptosis; it inhibits migration, invasion, angiogenesis and proliferation of cancer cells. Rotundic acid improves leptin sensitivity, regulates gut microbiota and reduces cellular senescence. Rotundic acid can be used in research related to hepatocellular carcinoma, obesity, aging, acute lung injury and type 2 diabetes.
  • HY-164395
    Sipuleucel-T
    		Modulator
    Sipuleucel-T is a cancer vaccine. Sipuleucel-T recognizes prostatic acid phosphatase (PAP), present PAP antigens, and stimulates the immune response against prostate cancer cells.
  • HY-164931
    MKP5 modulator-1
    		Modulator
    MKP5 modulator-1 (Page 14) is a MKP5 modulator with an IC50 of 2.46 μM. MKP5 modulator-1 can be used for the research of fibrotic diseases.