72141-57-2
Chemical Structure
Losulazine
- CAS. Nr.: 72141-57-2
- Formula:C27H22F4N4O3S
- Molecular Weight:558.55
IUPAC Name: (4-((4-fluorophenyl)sulfonyl)piperazin-1-yl)(4-((7-(trifluoromethyl)quinolin-4-yl)amino)phenyl)methanone
InChIKey: SYJKIRZBDWNJSB-UHFFFAOYSA-N
SMILES: O=C(N1CCN(S(=O)(C2=CC=C(C=C2)F)=O)CC1)C3=CC=C(NC4=C5C=CC(C(F)(F)F)=CC5=NC=C4)C=C3
Biological Activity: Losulazine is an orally active antihypertensive agent. Losulazine modulates acid phosphatase, 3β-hydroxysteroid dehydrogenase, and 17β-hydroxysteroid dehydrogenase activity. Losulazine can be used for the research of hypertension[1][2][3][4][5][6].
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Losulazine | 98.83% | Losulazine is an orally active antihypertensive agent. Losulazine modulates acid phosphatase, 3β-hydroxysteroid dehydrogenase, and 17β-hydroxysteroid dehydrogenase activity. Losulazine can be used for the research of hypertension. | ||||||||||||||||||||
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- [1]. Ray A, et al. Study on the activities of testes and accessory sex glands after losulazine treatment in rats. Toxicol Lett. 1994 Sep;73(3):175-83. [Content Brief]
- [2]. Mesfin, G. M.; et al. Testicular Lesions in Rats Treated with a Sympatholytic Hypotensive Agent (Losulazine). Journal of the American College of Toxicology 1989, 8 (3), 525-538.
- [3]. MESFIN, G. Mechanism of Anestrus in Rats Treated with an Antihypertensive Agent, Losulazine Hydrochloride*1. Toxicology and Applied Pharmacology 1987, 87 (1), 91-101.
- [4]. MORRIS, D. Effects of Losulazine on Rat Reproduction and Development*1. Fundamental and Applied Toxicology 1987, 9 (3), 573–587.
- [5]. Pan JT, et al. Comparison of the effects of losulazine and reserpine on central aminergic neurons. Toxicol Appl Pharmacol. 1993 Nov;123(1):26-33. [Content Brief]
- [6]. Gore R, et al. Losulazine, a new antihypertensive. Clin Pharmacol Ther. 1985 Aug;38(2):195-8. [Content Brief]
Keywords
