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  3. Prochloraz

Prochloraz (Synonyms: BTS 40542)

Cat. No.: HY-B0845
Handling Instructions

Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. Prochloraz inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s = 25 μM and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50 = 1 μM).

For research use only. We do not sell to patients.

Prochloraz Chemical Structure

Prochloraz Chemical Structure

CAS No. : 67747-09-5

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Description

Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. Prochloraz inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s = 25 μM and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50 = 1 μM).

Molecular Weight

376.67

Formula

C₁₅H₁₆Cl₃N₃O₂

CAS No.

67747-09-5

SMILES

O=C(N1C=CN=C1)N(CCC)CCOC2=C(Cl)C=C(Cl)C=C2Cl

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Keywords:

ProchlorazBTS 40542BTS40542BTS-40542FungalEstrogen Receptor/ERRAndrogen ReceptorAryl Hydrocarbon ReceptorAhRInhibitorinhibitorinhibit

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Prochloraz
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